Neuroprotective Effects of Potentilla Fulgens on Traumatic Brain Injury in Rats
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Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Sci Printers & Publ Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
OBJECTIVE: To investigate if Potentilla fulgens (P. fulgens) has any neuroprotective effects on traumatic brain injury in rats. STUDY DESIGN: Sprague-Dawley rats were subjected to traumatic brain injury with a weight-drop device using 300 g(-1) m weight-height impact. Sixty-four rats were divided into 4 groups: group 1 (vehicle-treated control), group 2 (P. fulgens 400 mg/kg/day, intraperitoneally [i.p.]), group 3 (vehicle-treated trauma), and group 4 (trauma+P. fulgens 400 mg/kg/day, i.p.). Distilled water was used as vehicle. All rats were decapitated 5 days after the induction of trauma, and the protective effects of P. fulgens were evaluated by histological, immunohistochemical, and biochemical analyses. RESULTS: Administration of P. fulgens at a dose of 400 mg/kg/day provided significant improvement in all of the histological, biochemical, and immunohistochemical analyses after the induction of traumatic brain injury. CONCLUSION: Although further studies are necessary to evaluate the time-and dose-dependent neuroprotective effects of P. fulgens, it may be a beneficial therapeutic agent for prevention of secondary neuronal damage following diffuse traumatic brain injury.
Açıklama
Anahtar Kelimeler
Cinquefoil, Craniocerebral Injuries, Head Injury, Head Trauma, Potentilla, Potentilla Fulgens, Rats, Laboratory, Silverweed, Traumatic Brain Injury, Traumatic Encephalopathy
Kaynak
Analytical and Quantitative Cytopathology and Histopathology
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
39
Sayı
1
