Effect of zoledronic acid application on different graft materials in calvarial bone defect models: An experimental analysis

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dc.contributor.authorKoparal M.
dc.contributor.authorGülsün B.
dc.contributor.authorDeveci E.
dc.contributor.authorAgacayak K.S.
dc.contributor.authorHamidi A.
dc.date.accessioned2024-04-24T18:45:57Z
dc.date.available2024-04-24T18:45:57Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: To determine the effect of zoledronic acid on graft materials in bone calvarial defects. STUDY DESIGN: Eighty adult (12 weeks) Sprague-Dawley male rats weighing from 300-350 g were divided into groups: calvarial defect, calvarial defect+synthetic graft, and calvarial defect+xenograft. All groups received zoledronate intravenously for a week after surgery and were sacrificed at either 6 or 12 weeks after their operation. The rat calvariae were fixed in 10% neutral buffered formalin before decalcification in 10% ethylenediaminetetraacetic acid for 20 days. Calvarial bone samples were then dehydrated and processed for embedding in paraffin wax. Sections 5 ?m thick were stained with hematoxylin and eosin and examined by light microscopy. RESULTS: The effects of zoledronic acid, a third-generation nitrogen-containing bisphosphonate, on different graft materials in rats with critical-size calvarial defects were analyzed and compared. Significantly less graft resorption was identified in zoledronic acid-treated rats that had received a xenograft than in either the untreated rats or those with a synthetic graft. In the xenograft group primary ossification was visible at week 12, and the graft had entered the bone to a greater extent than in the other experimental groups or in the control group. Osseous structures were also observed more clearly in this group than in the others. CONCLUSION: Zoledronic acid histopathologic bone graft stimulates bone formation. Zoledronic acid may be considered among the therapeutic methods available to improve the bone formation process in calvarial bone formation. © Science Printers and Publishers, Inc.en_US
dc.identifier.endpage125en_US
dc.identifier.issn0884-6812
dc.identifier.issue2en_US
dc.identifier.pmid27386633
dc.identifier.scopus2-s2.0-84963699552
dc.identifier.scopusqualityN/A
dc.identifier.startpage117en_US
dc.identifier.urihttps://hdl.handle.net/11468/24986
dc.identifier.volume38en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherScience Printers and Publishers Inc.en_US
dc.relation.ispartofAnalytical and Quantitative Cytology and Histology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntiresorptive Drugsen_US
dc.subjectBone Defecten_US
dc.subjectBone Dysplasiasen_US
dc.subjectBone Graftsen_US
dc.subjectBone Regenerationen_US
dc.subjectBone Remodelingen_US
dc.subjectBone Resorptionen_US
dc.subjectBone Resorption İnhibitorsen_US
dc.subjectBone Resorption İnhibitory Agentsen_US
dc.subjectDevelopmental Bone Diseaseen_US
dc.subjectFracture Healingen_US
dc.subjectOsteoconductionen_US
dc.subjectZoledronateen_US
dc.subjectZoledronic Aciden_US
dc.titleEffect of zoledronic acid application on different graft materials in calvarial bone defect models: An experimental analysisen_US
dc.titleEffect of zoledronic acid application on different graft materials in calvarial bone defect models: An experimental analysis
dc.typeArticleen_US

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