Demographic, clinical and laboratory characteristics of extrapulmonary tuberculosis: Eight-year results of a multicenter retrospective study in Turkey

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dc.authoridSAHIN, AHMET/0000-0002-8377-8293
dc.contributor.authorCelik, Mehmet
dc.contributor.authorGurbuz, Esra
dc.contributor.authorCicek, Yeliz
dc.contributor.authorBuyuktuna, Seyit Ali
dc.contributor.authorGundag, Omur
dc.contributor.authorGulderen Kuscu, Evrim
dc.contributor.authorMermutluoglu, Cigdem
dc.date.accessioned2025-02-22T14:08:50Z
dc.date.available2025-02-22T14:08:50Z
dc.date.issued2024
dc.departmentDicle Üniversitesien_US
dc.description.abstractExtrapulmonary tuberculosis (EPTB) is an important public health problem due to its diverse clinical presentations, diagnostic complexities, and significant impact on patient outcomes and public health. Our study aimed to understand the sociodemographic, clinical, and laboratory characteristics as well as diagnostic and treatment modalities of adult patients with EPTB. This is a multicentric retrospective study that covers patients with EPTB cases followed up from January 2015 to December 2022 among tuberculosis (TB) dispensaries and Infectious Diseases and Clinical Microbiology clinics of 15 hospitals located in various regions of Turkey. The study included 64.6% women with a mean age of 44 years and a mortality rate of 3.5% within 1 year of diagnosis. Initial constitutional symptoms were predominantly fatigue (57%) and anorexia (53.7%). The most commonly affected sites were the lymph nodes (49.1%) and pleura (9.7%). The lumbar region was particularly involved in cases with spinal TB. Diagnostic findings included acid-fast bacilli positivity in 27.5% of cases, tuberculosis polymerase chain reaction positivity in 41%, elevated adenosine deaminase levels in 91.2% (especially in pleural and peritoneal fluids), and mycobacterial culture positivity in 40.9%. Pathology slides showed granulomatous inflammation in 97.7%. Increased C-reactive protein (CRP) levels correlated with the number of organs affected. Anti-TB treatment-related hepatotoxicity was detected in 8.9% of patients. In this study, it is important to note that the lumbar region is predominantly affected with involvement in spinal region. CRP level was consistent with the number of organ involvements and was one of the most critical results of this study.en_US
dc.identifier.doi10.1177/10815589241299367
dc.identifier.issn1081-5589
dc.identifier.issn1708-8267
dc.identifier.pmid39508290en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1177/10815589241299367
dc.identifier.urihttps://hdl.handle.net/11468/29667
dc.identifier.wosWOS:001397577400001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofJournal of Investigative Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250222
dc.subjectExtrapulmonaryen_US
dc.subjecttuberculosisen_US
dc.subjectC-reactive proteinen_US
dc.subjectadenosine deaminaseen_US
dc.subjectlymph nodeen_US
dc.subjectcervicalen_US
dc.titleDemographic, clinical and laboratory characteristics of extrapulmonary tuberculosis: Eight-year results of a multicenter retrospective study in Turkeyen_US
dc.typeArticleen_US

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