Molecular investigation of the transmission dynamics of brucellosis observed among children in the province of south - East Anatolia, Turkey

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dc.authorid0000-0002-3446-7640en_US
dc.contributor.authorDal, Tuba
dc.contributor.authorDurmaz, Rıza
dc.contributor.authorCeylan, Ali
dc.contributor.authorBacalan, Fatma
dc.contributor.authorKaragöz, Alper
dc.contributor.authorÇelebi, Bekir
dc.contributor.authorYaşar, Ekrem
dc.contributor.authorKılıç, Selçuk
dc.contributor.authorAçıkgöz, Cibali
dc.date.accessioned2022-12-12T06:40:52Z
dc.date.available2022-12-12T06:40:52Z
dc.date.issued2018en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Halk Sağlığı Ana Bilim Dalıen_US
dc.description.abstractBackground: Brucellosis is a zoonotic disease caused by Brucella species. Although brucellosis is considered as an occupational disease in adults, recently it has become an infectious disease affecting all age groups, including children. Molecular epidemiological studies are crucial for control and treatment of disease in children. Objectives: This study aimed at identifying Brucella species, to detect antibiotic susceptibilities and define transmission dynamics between the Brucella isolates in children. Methods: A total of 77 Brucella isolates were identified by conventional and polymerase chain reaction methods. Anti - biotic susceptibilities were investigated by E - test strips. The isolates were genotyped by using multiple locus variable number tandem repeat analysis (MLVA) (MLVA - 16 Orsay), including 8 mini - satellite (panel 1) and 8 microsatellite (panel 2A and 2B) markers. Results: The mean age was 9.14±3.4 years. All patients had been consuming unpasteurized milk. All isolates were Brucella melitensis biovar 3. Only 2 isolates were resistant to ceftriaxone, while the other isolates were susceptible to other antimicrobial agents. The MLVA - 16 typing revealed 42 MLVA profiles. Eighteen profiles included 2 or more isolates, indicating a clustering rate of 66.7%. Twenty - four isolates showed a unique profile. Single locus, double locus, and 3 locus variants were detected in 32, 26, and 15 isolates, respectively. Bruce 30, Bruce 16, Bruce 9, Bruce 7, and Bruce 4 were highly discriminatory loci, respectively. All strains were defined as genotype 122, according to MLVA - 11, and genotype 43 according to MLVA - 8, and were in the Eastern Mediterranean genotype. Conclusions: High clustering rate revealed that brucellosis among the children mainly resulted from common sources. Controlling animal movements and avoiding contaminated milk products have an importance to interrupt spread of brucellosis in children.en_US
dc.identifier.citationDal, T., Durmaz, R., Ceylan, A., Bacalan, F., Karagöz, A. ve Çelebi, B. (2018). Molecular investigation of the transmission dynamics of brucellosis observed among children in the province of south - East Anatolia, Turkey. Jundishapur Journal of Microbiology, 11 (3).en_US
dc.identifier.doi10.5812/jjm.58857en_US
dc.identifier.issn2008-3645
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85044940546en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.urihttps://brieflands.com/articles/jjm-58857.html
dc.identifier.urihttps://hdl.handle.net/11468/11019
dc.identifier.volume11en_US
dc.identifier.wosWOS:000428203400006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorCeylan, Ali
dc.language.isoenen_US
dc.publisherKowsar Medical Instituteen_US
dc.relation.ispartofJundishapur Journal of Microbiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBrucellaen_US
dc.subjectChilden_US
dc.subjectEpidemiologyen_US
dc.titleMolecular investigation of the transmission dynamics of brucellosis observed among children in the province of south - East Anatolia, Turkeyen_US
dc.typeArticleen_US

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