Reduced graphene oxide/platinum nanoparticles/nafion nanocomposite as a novel 2D electrochemical sensor for voltammetric determination of aliskiren

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dc.contributor.authorAtes, Ali Kemal
dc.contributor.authorEr, Engin
dc.contributor.authorCelikkan, Huseyin
dc.contributor.authorErk, Nevin
dc.date.accessioned2024-04-24T16:24:05Z
dc.date.available2024-04-24T16:24:05Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractThis study describes the fabrication of a sensitive and selective graphene-based electrochemical nanosensor for the detection of aliskiren (ALS). It is the first research study where the electrochemical oxidation and determination of ALS were investigated by cyclic voltammetry (CV) and adsorptive stripping differential pulse voltammetry (AdsDPV) using a 2D nanocomposite electrode modified with reduced graphene oxide/platinum nanoparticles/nafion (rGO/PtNPs/NFN/GCE). An rGO/PtNP nanocomposite was synthesized directly from graphene oxide (GO) and platinum salt using a single-step chemical reduction method. The synthesized rGO/PtNPs were characterized by X-ray diffraction (XRD) and transmission electron microscopy (TEM). The developed sensor exhibited excellent electrocatalytic activity (i.e. shifting the potential from 1225 to 1059 mV) towards the oxidation of ALS. The voltammetric responses of ALS presented a good linearity with an increase in concentration within two concentration ranges of 0.045-0.45 mu M and 0.45-2.70 mu M with a low detection limit of 8.2 nM. The analytical applicability of the proposed sensor was demonstrated by determining ALS with the recovery result of 97.0% in human blood plasma. The results strongly suggested that the proposed sensor could be promising as an alternative analytical approach for routine analysis of ALS in clinical samples.en_US
dc.description.sponsorshipAnkara University Scientific Research Projects Coordination Unit [15B0237001, 15L0237007]en_US
dc.description.sponsorshipThis research was supported by the Ankara University Scientific Research Projects Coordination Unit (Project Numbers: 15B0237001, 15L0237007).en_US
dc.identifier.doi10.1039/c7nj00569e
dc.identifier.endpage15326en_US
dc.identifier.issn1144-0546
dc.identifier.issn1369-9261
dc.identifier.issue24en_US
dc.identifier.scopus2-s2.0-85037667938
dc.identifier.scopusqualityQ2
dc.identifier.startpage15320en_US
dc.identifier.urihttps://doi.org/10.1039/c7nj00569e
dc.identifier.urihttps://hdl.handle.net/11468/16475
dc.identifier.volume41en_US
dc.identifier.wosWOS:000417058800069
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherRoyal Soc Chemistryen_US
dc.relation.ispartofNew Journal of Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleReduced graphene oxide/platinum nanoparticles/nafion nanocomposite as a novel 2D electrochemical sensor for voltammetric determination of aliskirenen_US
dc.titleReduced graphene oxide/platinum nanoparticles/nafion nanocomposite as a novel 2D electrochemical sensor for voltammetric determination of aliskiren
dc.typeArticleen_US

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