The Effect of Dietary Supplements on Healing of Alloplastic Bone Grafted Defects in Rat Tibia

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dc.contributor.authorKaya, A.
dc.contributor.authorAktas, A.
dc.contributor.authorAkdemir, M. F.
dc.contributor.authorKaya, B.
dc.contributor.authorDeveci, E.
dc.date.accessioned2024-04-24T17:24:10Z
dc.date.available2024-04-24T17:24:10Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of this investigation was to evaluate the potential effects of the systemically delivered combination of calcium, zinc and vit-d supplementation of the locally applied alloplastic bone graft. 28 male Wistar albino rats were used in this study. In each animal, bone defects (10 mm length (sic) 3 mm width (sic) 2 mm depth) were created in the tibias. The animals were divided into four groups. In Group 1 (Control Group) rats were fed with standard rat diet. In Group 2 (Calcium Group) rats received calcium carbonate (15 mg/kg body weight) suspended in saline. In Group 3 (Calcium/Zinc Group) rats received calcium carbonate (15 mg/kg body weight) and zinc sulfate (4 mg/kg body weight) suspended in saline. In Group 4 (Calcium/Vitamin D Group) rats received calcium carbonate (15 mg/kg body weight) and Vitamin D (500 IU/kg body weight) suspended in olive oil. Histopathological analysis of samples was performed to evaluate the process of osteoblastic activity, matrix formation, trabecular bone formation and myeloid tissue in bone defects. Total amounts of osteoblastic activity, matrix formation, trabecular bone formation and myeloid tissue in Ca Group (p= 0.002), Ca/Zinc Group (p= 0.002), and Ca/Vit.D Group (p= 0.001) were significantly higher than in Control Group. The total amounts of Ca/Vit.D Group were significantly different than Control Group and Ca Group. The results of the present study indicated that the oral calcium carbonate supplementation combination with zinc may have systemic effects on accelerating bone regeneration in alloplastic bone grafted tibial defects. Further human studies involving long-term follow up and different type of bone grafts should be conducted.en_US
dc.identifier.doi10.4067/S0717-95022015000200049
dc.identifier.endpage731en_US
dc.identifier.issn0717-9502
dc.identifier.issn0717-9367
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84939551465
dc.identifier.scopusqualityQ3
dc.identifier.startpage725en_US
dc.identifier.urihttps://doi.org/10.4067/S0717-95022015000200049
dc.identifier.urihttps://hdl.handle.net/11468/19487
dc.identifier.volume33en_US
dc.identifier.wosWOS:000362256800048
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherSoc Chilena Anatomiaen_US
dc.relation.ispartofInternational Journal of Morphology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDietary Supplementsen_US
dc.subjectBone Healingen_US
dc.subjectBone Grafteden_US
dc.subjectBone Defectsen_US
dc.subjectTibial Defectsen_US
dc.subjectAlloplastic Boneen_US
dc.titleThe Effect of Dietary Supplements on Healing of Alloplastic Bone Grafted Defects in Rat Tibiaen_US
dc.titleThe Effect of Dietary Supplements on Healing of Alloplastic Bone Grafted Defects in Rat Tibia
dc.typeArticleen_US

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