Cell-specific expression pattern of toll-like receptors and their roles in animal reproduction

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dc.contributor.authorAtlı, Mehmet Osman
dc.contributor.authorHitit, Mustafa
dc.contributor.authorÖzbek, Mehmet
dc.contributor.authorKöse, Mehmet
dc.contributor.authorBozkaya, Faruk
dc.contributor.orcid0000-0001-9853-5334
dc.contributor.orcid0000-0001-5636-061X
dc.contributor.orcid0000-0003-0070-8458
dc.date.accessioned2024-04-24T17:56:02Z
dc.date.available2024-04-24T17:56:02Z
dc.date.issued2022
dc.departmentDicle Üniversitesi, Veteriner Fakültesi, Klinik Bilimler Bölümüen_US
dc.description.abstractToll-like receptors (TLRs), a part of the innate immune system, have critical roles in protection against infections and involve in basic pathology and physiology. Secreted molecules from the body or pathogens could be a ligand for induction of the TLR system. There are many immune and non-immune types of cells that express at a least single TLR on their surface or cytoplasm. Those cells may be a player in a defense system or in the physiological regulation mechanisms. Reproductive tract and organs contain different types of cells that have essential functions such as hormone production, providing an environment for embryo/fetus, germ cell production, etc. Although lower parts of reproductive organs are in a relationship with outsider contaminants (bacteria, viruses, etc.), upper parts should be sterile to provide a healthy pregnancy and germ cell production. In those areas, TLRs bear controller or regulator roles. In this chapter, we will provide current information about physiological functions of TLR in the cells of the reproductive organs and tract, and especially about their roles in follicle selection, maturation, follicular atresia, ovulation, corpus luteum (CL) formation and regression, establishment and maintenance of pregnancy, sperm production, maturation, capacitation as well as the relationship between TLR polymorphism and reproduction in domestic animals. We will also discuss pathogen-associated molecular patterns (PAMPs)-induced TLRs that involve in reproductive inflammation/pathology.en_US
dc.identifier.citationAtlı, M. O., Hitit, M., Özbek, M., Köse, M. ve Bozkaya, F. (2022). Cell-specific expression pattern of toll-like receptors and their roles in animal reproduction. Handbook of Experimental Pharmacology, 276, 65-93.
dc.identifier.doi10.1007/164_2022_584
dc.identifier.endpage93en_US
dc.identifier.issn0171-2004
dc.identifier.pmid35434748
dc.identifier.scopus2-s2.0-85131702265
dc.identifier.scopusqualityQ1
dc.identifier.startpage65en_US
dc.identifier.urihttps://doi.org/10.1007/164_2022_584
dc.identifier.urihttps://hdl.handle.net/11468/23202
dc.identifier.volume276en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringer Science and Business Media Deutschland GmbHen_US
dc.relation.ispartofHandbook of Experimental Pharmacology
dc.relation.publicationcategoryKitap Bölümü - Uluslararasıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDomestic animalsen_US
dc.subjectPolymorphismen_US
dc.subjectReproductive cellsen_US
dc.subjectToll-like receptorsen_US
dc.titleCell-specific expression pattern of toll-like receptors and their roles in animal reproductionen_US
dc.titleCell-specific expression pattern of toll-like receptors and their roles in animal reproduction
dc.typeBook Chapteren_US

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