In-vitro Antioxidant, Cytotoxic, Cholinesterase Inhibitory Activities and Anti-Genotoxic Effects of Hypericum retusum Aucher Flowers, Fruits and Seeds Methanol Extracts in Human Mononuclear Leukocytes

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dc.contributor.authorKeskin, Cumali
dc.contributor.authorAktepe, Necmettin
dc.contributor.authorYukselten, Yunus
dc.contributor.authorAsuman
dc.contributor.authorBoga, Mehmet
dc.date.accessioned2024-04-24T17:49:48Z
dc.date.available2024-04-24T17:49:48Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe present study investigates the antioxidant, anticancer, anticholinesterase, anti-genotoxic activities and phenolic contents of flower, fruit and seed methanol extracts of Hypericum retusum AUCHER. The amounts of protocatechuic acid, catechin, caffeic acid and syringic acid in methanol extracts were determined by HPLC. Total phenolic content of H. retusum seed extract was found more than fruit and flower extracts. The DPPH free radical scavenging activity of flower and seed methanol extracts showed close activity versus BHT as control. Among three extracts of H. retusum only flower methanol extract was exhibited considerable cytotoxic activities against to HeLa and NRK-52E cell lines. Moreover, seed methanol extract showed both acetyl and butyrl-cholinesterase inhibitory activity. The highest anti-genotoxic effects were seen 25 and 50 mu g/mL concentrations. In this study, the extracts showed a strong antioxidant and anti-genotoxic effect. The seed extract was more efficient-than extracts of fruit and flowers. Our results suggest that the antioxidant and anti-genotoxic effects of extracts depend on their phenolic contents. Further studies should evaluate the in-vitro and in-vivo the benefits of H. retusum seed methanol extracts.en_US
dc.description.sponsorshipMardin Artuklu University [MAU-BAP-12-SYO-04]en_US
dc.description.sponsorshipThe present study was supported by Mardin Artuklu University. Grant number: MAU-BAP-12-SYO-04. The authors also are grateful for Dr. Ersin Kilinc for kind advice and help throughout this work.en_US
dc.identifier.endpage220en_US
dc.identifier.issn1735-0328
dc.identifier.issn1726-6890
dc.identifier.issue1en_US
dc.identifier.pmid28496476
dc.identifier.startpage210en_US
dc.identifier.urihttps://hdl.handle.net/11468/22975
dc.identifier.volume16en_US
dc.identifier.wosWOS:000396490200019
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherShaheed Beheshti Univ, Sch Pharmacyen_US
dc.relation.ispartofIranian Journal of Pharmaceutical Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHypericum Retusum Aucheren_US
dc.subjectAntioxidanten_US
dc.subjectCytotoxicen_US
dc.subjectAnticholinesteraseen_US
dc.subjectAntigenotoxicen_US
dc.titleIn-vitro Antioxidant, Cytotoxic, Cholinesterase Inhibitory Activities and Anti-Genotoxic Effects of Hypericum retusum Aucher Flowers, Fruits and Seeds Methanol Extracts in Human Mononuclear Leukocytesen_US
dc.titleIn-vitro Antioxidant, Cytotoxic, Cholinesterase Inhibitory Activities and Anti-Genotoxic Effects of Hypericum retusum Aucher Flowers, Fruits and Seeds Methanol Extracts in Human Mononuclear Leukocytes
dc.typeArticleen_US

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