Correlations Between Oncotype DX Recurrence Score and Classic Risk Factors in Early Breast Cancer: Results of A Prospective Multicenter Study in Turkey

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dc.contributor.authorOzmen, Vahit
dc.contributor.authorAtasoy, Ajlan
dc.contributor.authorGokmen, Erhan
dc.contributor.authorOzdogan, Mustafa
dc.contributor.authorGuler, Nilufer
dc.contributor.authorUras, Cihan
dc.contributor.authorOk, Engin
dc.date.accessioned2024-04-24T17:27:30Z
dc.date.available2024-04-24T17:27:30Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: Breast cancer is the most common malignancy among Turkish women and the rate of early stage disease is increasing. The Oncotype DX 21-gene assay is predictive of distant recurrence in ER-positive, HER2-negative early breast cancer. We aimed to evaluate the correlations between Recurrence Score (RS) and routine risk factors. Materials and Methods: Ten academic centers across Turkey participated in this prospective trial. Consecutive patients with breast cancer who had pT1-3, pN0-N1mic, ER-positive, and HER2-negative tumors were identified at tumor conferences. Both pre- and post-RS treatment decisions and physician perceptions were recorded on questionnaire forms. Correlations between RS and classic risk factors were evaluated using univariate and multivariate analyses. Results: Ten centers enrolled a total of 165 patients. The median tumor size was 2 cm. Of the 165 patients, 57% had low RS, 35% had intermediate RS, and 8% had high RS, respectively. Multivariate analysis indicated that progesterone receptor (PR) and Ki67 scores were significantly related to RS. Conclusion: Oncotype DX Recurrence Score does not seem to have a significant correlation with the majority of classic risk factors, but it may have a correlation with PR score and Ki67 score.en_US
dc.description.sponsorshipGenomic Health (Inc.; California, USA)en_US
dc.description.sponsorshipGenomic Health (Inc.; California, USA) has provided an educational grant for the genomic testing in this trial.en_US
dc.identifier.doi10.5152/tjbh.2016.2874
dc.identifier.endpage111en_US
dc.identifier.issn2149-1976
dc.identifier.issue3en_US
dc.identifier.pmid28331745
dc.identifier.startpage107en_US
dc.identifier.urihttps://doi.org/10.5152/tjbh.2016.2874
dc.identifier.urihttps://hdl.handle.net/11468/20003
dc.identifier.volume12en_US
dc.identifier.wosWOS:000382992100003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofJournal of Breast Health
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOncotype Dxen_US
dc.subjectPathologyen_US
dc.subjectHormone Receptorsen_US
dc.subjectKi67en_US
dc.subjectCorrelationen_US
dc.titleCorrelations Between Oncotype DX Recurrence Score and Classic Risk Factors in Early Breast Cancer: Results of A Prospective Multicenter Study in Turkeyen_US
dc.titleCorrelations Between Oncotype DX Recurrence Score and Classic Risk Factors in Early Breast Cancer: Results of A Prospective Multicenter Study in Turkey
dc.typeArticleen_US

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