Sertoli-Leydig cell tumor of the ovary: A clinicopathologic study of 10 cases

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dc.contributor.authorAyhan A.
dc.contributor.authorTuncer Z.S.
dc.contributor.authorHakverdi A.U.
dc.contributor.authorYüce K.
dc.contributor.authorAyhan A.
dc.date.accessioned2024-04-24T18:44:05Z
dc.date.available2024-04-24T18:44:05Z
dc.date.issued1996
dc.departmentDicle Üniversitesien_US
dc.description.abstractTen patients with Sertoli-Leydig cell tumors of the ovary treated consecutively were analyzed retrospectively for clinicopathological characteristics, treatment modalities and survival. All patients were subjected to a surgical procedure including unilateral salpingoophorectomy (USO) in 5, total abdominal hysterectomy, bilateral salpingoophorectomy (TAH+BSO) in 2, TAH+BSO and omentectomy and pelvic and paraaortic lymphadenectomy and appendicectomy in 3 patients. Following surgery, 5 patients were subjected to adjuvant VAC (vincristine+actinomycine-D+cyclophosphamide) chemotherapy. Sertoli-Leydig cell tumors constitued 0.6% of all ovarian neoplasms in our institution (10/1621). The mean age at diagnosis was 28.2 years. Of the patients, 8 had stage IA, one had IB and one had stage III disease at surgery. Bilaterality was observed in two patients (20.0%). Four patients had poorly-differentiate tumors, of whom 1 had a retiform pattern and 1 had a heterologue element, with marked mitosis whereas the others had well - or moderately - differentiated tumors. Only one patient presented with recurrence during pregnancy and died 16 months after initial surgery. Since most of the patients present with stage IA disease, a favorable outcome can be achieved in most of them and conservative surgery seems to be the treatment of choice in younger patients. However, late recurrences even in early stages, especially in patients with poorly-differentiated tumors, can be detected, resulting in a fatal outcome despite any form of aggressive therapy.en_US
dc.identifier.endpage78en_US
dc.identifier.issn0392-2936
dc.identifier.issue1en_US
dc.identifier.pmid8750520
dc.identifier.scopus2-s2.0-9044234407
dc.identifier.scopusqualityN/A
dc.identifier.startpage75en_US
dc.identifier.urihttps://hdl.handle.net/11468/24552
dc.identifier.volume17en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.relation.ispartofEuropean Journal of Gynaecological Oncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSertoli-Leydig Tumoren_US
dc.subjectSx Cord-Stromal Tumoren_US
dc.titleSertoli-Leydig cell tumor of the ovary: A clinicopathologic study of 10 casesen_US
dc.titleSertoli-Leydig cell tumor of the ovary: A clinicopathologic study of 10 cases
dc.typeArticleen_US

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