Effect of dietary zearalenone on the performance, reproduction tract and serum biochemistry in young rats

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dc.contributor.authorDenli, Muzaffer
dc.contributor.authorCarlos Blandon, Juan
dc.contributor.authorSalado, Silvia
dc.contributor.authorElena Guynot, Maria
dc.contributor.authorFrancisco Perez, Jose
dc.date.accessioned2024-04-24T16:24:45Z
dc.date.available2024-04-24T16:24:45Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe present study was conducted to determine the toxic dose response of a chronic dietary Zearalenone (ZEA) in weaned young rats. Sixty, 21-day-old, Sprague Dawley female rats were randomly allocated to five groups of four replicate cages containing three rats. Rats were fed diets with increasing amounts of ZEA (0, 0.5, 0.9, 1.8 and 3.6 mg/kg) for 4 weeks. Daily feed intake was reduced (P < .05) by feeding the ZEA diets with 0.9 and 3.6 mg ZEA/kg feed. Rats fed the diet containing 1.8 mg ZEA/kg increased (P < .05) the body weight gain (BWG) and reduced (P < .05) feed conversion rate (FCR) as compared to the control group. The two highest levels of dietary ZEA also increased (P < .05) the weight of the uterus. However, ovaries' weight, timing of vaginal opening and the inter-oestrous interval were not affected by increasing the doses of dietary ZEA (P > .05). Similarly, serum concentrations of total protein, follicle-stimulating hormone and alanine aminotransferase, aspartate aminotransferase and alkaline phosphate activities were not altered by the ZEA treatments. In conclusion, our results indicated that a chronic dietary consumption of ZEA at concentrations of 1.8 mg ZEA/kg increases the BWG and the uterus weight of weaning female rats.en_US
dc.description.sponsorshipTorres Quevedo [PTQ2004-0869]; [299 PROFIT FIT-0300-2003-335]; [CDTI 20050012]en_US
dc.description.sponsorshipThis work, part of MONALISA EUREKA Project E! 3025, was supported by 299 PROFIT FIT-0300-2003-335, CDTI 20050012, and Torres Quevedo PTQ2004-0869.en_US
dc.identifier.doi10.1080/09712119.2016.1251929
dc.identifier.endpage622en_US
dc.identifier.issn0971-2119
dc.identifier.issn0974-1844
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85034747877
dc.identifier.scopusqualityQ2
dc.identifier.startpage619en_US
dc.identifier.urihttps://doi.org/10.1080/09712119.2016.1251929
dc.identifier.urihttps://hdl.handle.net/11468/16842
dc.identifier.volume45en_US
dc.identifier.wosWOS:000416541400007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Applied Animal Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectZearalenoneen_US
dc.subjectUterusen_US
dc.subjectOvariesen_US
dc.subjectBiochemistryen_US
dc.subjectWeaning Ratsen_US
dc.titleEffect of dietary zearalenone on the performance, reproduction tract and serum biochemistry in young ratsen_US
dc.titleEffect of dietary zearalenone on the performance, reproduction tract and serum biochemistry in young rats
dc.typeArticleen_US

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