Relationship between pituitary siderosis and endocrinological disorders in pediatric patients with beta-thalassemia

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dc.authorid0000-0002-3037-2353en_US
dc.authorid0000-0002-9586-2425en_US
dc.contributor.authorYılmaz, Kamil
dc.contributor.authorKan, Ahmet
dc.contributor.authorÇetinçakmak, Mehmet Guli
dc.contributor.authorUzel, V. Hülya
dc.contributor.authorYılmaz, Deniz
dc.contributor.authorDeniz, Muhammed Akif
dc.contributor.authorHattapoğlu, Salih
dc.date.accessioned2021-04-09T11:16:14Z
dc.date.available2021-04-09T11:16:14Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, RadyolojiAna Bilim Dalıen_US
dc.descriptionWOS:000612028500007
dc.descriptionPMID:33633906
dc.descriptionPMC7899051
dc.description.abstractIntroduction Excess iron accumulation occurs mainly in organs such as reticuloendothelial cells, the pituitary gland, and the pancreas in beta-thalassemia because of blood transfusions. In the present study, it was aimed to investigate the relationship between T2* values on magnetic resonance imaging (MRI) and clinically diagnosed pituitary endocrinological disorders in children with thalassemia major. Methods This study enrolled patients diagnosed with beta-thalassemia at pediatric hematology outpatient clinics. In the study, in addition to the medical history of the patients, routinely performed tests, including hemoglobin electrophoresis, routine biochemical tests, and tests for pubertal development (follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol, testosterone, etc.), as well as iron deposition measured by hepatic MRI T2* (STAR) sequence, were retrospectively assessed. A total of 29 patients were enrolled. Results Hypothyroidism was detected in 34.6% (9/26) of patients, short stature in 37% (10/27), and pubertal retardation in 50% (14/28) of the patients. There was no significant correlation between hypothyroidism and pituitary MRI T2* values. No significant correlation was found between laboratory parameters and pituitary MRI examination. Although the sensitivity of T2* levels could rise above 80%, their specificity remained low. This is one of the major limitations of the pituitary MR T2* study for the prediction of short stature. The best lower cut-off level of MR T2* to predict short stature was found 14.6 ms. Conclusion The diagnostic specificity pituitary MR examination levels for short stature were detected as low. Thus, the clinical standardization and validation of pituitary MR T2* values examination are needed before clinical follow-up and multifaceted studies are needed.en_US
dc.identifier.citationYılmaz, K., Kan, A., Çetinçakmak, M.G., Uzel, V.H.Yılmaz, D., Deniz, M.A. ve diğerleri. (2021). Relationship between pituitary siderosis and endocrinological disorders in pediatric patients with beta-thalassemia. Cureus, 13(1), 1-8.en_US
dc.identifier.doi10.7759/cureus.12877
dc.identifier.endpage8en_US
dc.identifier.issn2168-8184
dc.identifier.issue1en_US
dc.identifier.pmid33633906
dc.identifier.startpage1en_US
dc.identifier.urihttps://assets.cureus.com/uploads/original_article/pdf/49744/1614004630-20210222-14459-1uptawr.pdf
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/33633906/
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899051/
dc.identifier.urihttps://hdl.handle.net/11468/6668
dc.identifier.volume13en_US
dc.identifier.wosWOS:000612028500007
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorYılmaz, Kamil
dc.institutionauthorKan, Ahmet
dc.institutionauthorUzel, V. Hülya
dc.institutionauthorYılmaz, Deniz
dc.institutionauthorDeniz, Muhammed Akif
dc.institutionauthorHattapoğlu, Salih
dc.language.isoenen_US
dc.publisherCureus Inc.en_US
dc.relation.ispartofCureus
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBeta thalassemiaen_US
dc.subjectPituitary mrien_US
dc.subjectSiderosisen_US
dc.subjectT2en_US
dc.titleRelationship between pituitary siderosis and endocrinological disorders in pediatric patients with beta-thalassemiaen_US
dc.titleRelationship between pituitary siderosis and endocrinological disorders in pediatric patients with beta-thalassemia
dc.typeArticleen_US

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