Xanthine oxidase inhibitory activity and uric acid dissolution power of some plant extracts: In vitro therapeutical approach for gout treatment

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dc.authorid0000-0003-2254-3578en_US
dc.authorid0000-0001-6075-7601en_US
dc.authorid0000-0001-6737-6414en_US
dc.authorid0000-0002-4090-7227en_US
dc.authorid0000-0002-8006-2054en_US
dc.authorid0000-0001-5196-3892en_US
dc.authorid0009-0002-3396-794Xen_US
dc.authorid0000-0003-3947-9867en_US
dc.contributor.authorBouakkaz, Hicham
dc.contributor.authorDjeridane, Amar
dc.contributor.authorMahfoudi, Reguia
dc.contributor.authorYılmaz, Mustafa Abdullah
dc.contributor.authorÇakır, Oğuz
dc.contributor.authorTarhan, Abbas
dc.contributor.authorLassakeur, Zakaria
dc.contributor.authorYousfi, Mohamed
dc.date.accessioned2024-10-22T13:03:11Z
dc.date.available2024-10-22T13:03:11Z
dc.date.issued2024en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractElevated serum levels of uric acid are associated with an increased risk of hyperuricemia and gout. Recent attention has focused on the bioactive properties of plant extracts in preventing disease. Therefore, this study investigated the effects of 16 different extracts from four common plants on the inhibition of xanthine oxidase and the dissolution of uric acid, as well as the quantification of certain phytoconstituents and their haemolytic effects on human red blood cells. Results from quantitative phytochemical analysis revealed significant (p < 0.0001) intra- and inter-specific variability in total phenols, flavonoids, tannins, uric acid, sodium, potassium, and calcium depending on the studied species and the type of solvent used in extraction. A total of 19 phenolic compounds were characterized and quantified using an ultrahigh-performance liquid chromatograph coupled with an electrospray ionization source operating in both negative and positive ionization modes mass spectrometry, including phenolic acids, flavonoids and other polyphenols. The in vitro antigout activity results indicated that all extracts had the ability to express the inhibitory activity of xanthine oxidase and to dissolve uric acid at different levels. Therefore, the acetonic extracts of Cistus creticus L., Cistaceae, and Plantago ciliata Desf., Plantaginaceae, had the most significant xanthine oxidase inhibiting effect with values of 13.480 ± 0.596 and 13.020 ± 0.627 µg of allopurinol/mg of dry residue, respectively. Moreover, their aqueous extracts showed the highest dissolving properties of uric acid (solubilities > 450 mg uric acid/l). These extracts also showed no toxic effect against isolated human erythrocytes and may be able to help improve the efficacy of new therapies for gouty arthritis. Graphical Abstract: (Figure presented.)en_US
dc.identifier.citationBouakkaz, H., Djeridane, A., Mahfoudi, R., Yılmaz, M. A., Çakır, O., Tarhan, A. ve diğerleri. (2024). Xanthine oxidase inhibitory activity and uric acid dissolution power of some plant extracts: In vitro therapeutical approach for gout treatment. Revista Brasileira de Farmacognosia, 1-13.en_US
dc.identifier.endpage13en_US
dc.identifier.issn1981-528X
dc.identifier.scopus2-s2.0-85202619229
dc.identifier.scopusqualityQ2
dc.identifier.startpage1en_US
dc.identifier.urihttps://link.springer.com/article/10.1007/s43450-024-00585-w
dc.identifier.urihttps://hdl.handle.net/11468/28860
dc.identifier.wosWOS:001303214000001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorYılmaz, Mustafa Abdullah
dc.institutionauthorÇakır, Oğuz
dc.institutionauthorTarhan, Abbas
dc.language.isoenen_US
dc.publisherSpringer Science and Business Media Deutschland GmbHen_US
dc.relation.ispartofRevista Brasileira de Farmacognosia
dc.relation.isversionof10.1007/s43450-024-00585-wen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntigouten_US
dc.subjectPhenolicsen_US
dc.subjectPhytoconstituentsen_US
dc.subjectPlant extractsen_US
dc.subjectToxicityen_US
dc.titleXanthine oxidase inhibitory activity and uric acid dissolution power of some plant extracts: In vitro therapeutical approach for gout treatmenten_US
dc.titleXanthine oxidase inhibitory activity and uric acid dissolution power of some plant extracts: In vitro therapeutical approach for gout treatment
dc.typeArticleen_US

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