Opioids inhibit angiogenesis in a chorioallantoic membrane model

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dc.contributor.authorKaraman H.
dc.contributor.authorTufek A.
dc.contributor.authorKaraman E.
dc.contributor.authorTokgoz O.
dc.date.accessioned2024-04-24T18:46:27Z
dc.date.available2024-04-24T18:46:27Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Angiogenesis is an important characteristic of cancer. Switching from the avascular phase to the vascular phase is a necessary process for tumor growth. Therefore, research in cancer treatment has focused on angiogenesis as a drug target. Despite the widespread use of opioids to treat pain in patients with cancer, little is known about the effect of these drugs on vascular endothelium and angiogenesis. Objectives: We aimed to investigate the efficacies of morphine, codeine, and tramadol in 3 different concentrations on angiogenesis in hens’ eggs. Study Design: This is a prospective, observational, controlled, in-vivo animal study. Setting: Single academic medical center. Methods: This study was conducted on the chorioallantoic membrane (CAM) of fertilized hens’ eggs. The efficacies of morphine, codeine, and tramadol in 3 different concentrations were evaluated on angiogenesis in a total of 165 hens’ eggs. Results: Statistically significant differences were found between drug-free agarose used as a negative control and concentrations of morphine of 10 ?M and 1 ?M, a concentration of tramadol of 10 ?M, and concentrations of codeine of 10 ?M and 1 ?M. Concentrations of morphine of 10 ?M and 1 ?M showed strong antiangiogenic effects. While codeine had strong antiangiogenic effects at high concentrations, at 0.1 ?M it was shown to have weak antiangiogenic effects. However, tramadol at a concentration of 10 ?M had only weak antiangiogenic effects. Limitations: This is just a CAM model study. Conclusion: In this study, we tested the effects of 3 different opioid drugs on angiogenesis in 3 different concentrations, and we observed that morphine was a good anti-angiogenic agent, but tramadol and codeine only had anti-angiogenic effects at high doses. © 2017, American Society of Interventional Pain Physicians. All rights reserved.en_US
dc.identifier.endpageSE21en_US
dc.identifier.issn1533-3159
dc.identifier.issue2en_US
dc.identifier.pmid28226338
dc.identifier.scopus2-s2.0-85016181003
dc.identifier.scopusqualityQ1
dc.identifier.startpageSE11en_US
dc.identifier.urihttps://hdl.handle.net/11468/25205
dc.identifier.volume20en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherAmerican Society of Interventional Pain Physiciansen_US
dc.relation.ispartofPain Physician
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAngiogenesisen_US
dc.subjectBevacizumaben_US
dc.subjectChorioallantoic Membrane (Cam)en_US
dc.subjectCodeineen_US
dc.subjectMorphineen_US
dc.subjectOpioiden_US
dc.subjectTramadolen_US
dc.titleOpioids inhibit angiogenesis in a chorioallantoic membrane modelen_US
dc.titleOpioids inhibit angiogenesis in a chorioallantoic membrane model
dc.typeArticleen_US

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