Comparison of the Effectiveness of Thymoquinone, St. John Wort Oil and Silver Sulfadiazine in Experimental Burn Wounds

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dc.authoridCANBAZ, Yasin/0009-0000-3903-5532
dc.authoridTuran Canbaz, Esra/0009-0000-2832-5243
dc.authoridmercantepe, tolga/0000-0002-8506-1755
dc.authoridErten, Remzi/0000-0001-7775-5792
dc.authoridRAGBETLI, Murat Cetin/0000-0002-8189-264X
dc.authoridalp, hamit hakan/0000-0002-9202-4944
dc.authoridTUREL, IDRIS/0000-0001-9865-1685
dc.contributor.authorCanbaz, Yasin
dc.contributor.authorKarakol, Percin
dc.contributor.authorErten, Remzi
dc.contributor.authorMercantepe, Tolga
dc.contributor.authorAlp, Hamit Hakan
dc.contributor.authorCanbaz, Esra Turan
dc.contributor.authorTurel, Idris
dc.date.accessioned2025-02-22T14:08:54Z
dc.date.available2025-02-22T14:08:54Z
dc.date.issued2024
dc.departmentDicle Üniversitesien_US
dc.description.abstractWe aimed to compare the effectiveness of thymoquinone (TQ), the most important bioactive component of black cumin, St. John wort (SJW) oil, a traditional medicinal plant used in burns, and silver sulfadiazine (AgSD), a well-known antiinflammatory agent used in modern medicine, in an experimental burn rat-model. Sixty-three Wistar-Albino rats were randomly divided into 9 groups (n = 7). TQ and SJW were administered topically and systemically but AgSD was applied topically. Epithelialization, inflammatory cell response, granulation tissue, vascularization, and fibrosis were evaluated. Malondialdehyde (MDA), total antioxidant status (TAS), total oxidant status (TOS), vitamin E, 8-hydroxy-deoxyguanosine (8-OHdG), coenzyme Q10 (CoQ10) were analyzed in serum. Topical TQ accelerated the epithelialization, enabled granulation, vascularization, and fibrosis in wounds (P = .001). Topical and systemic TQ increased Vitamin E levels (P = .003) but reduced TOS and 8-OHdG levels (P = .001). Topical SJW reduced granulation and vascularization. Topical and systemic SJW decreased TOS, MDA, and 8-OHdG levels (P = .001) but increased TAS (P = .001) and Vitamin E levels (P = .003). Topical AgSD reduced TOS, 8-OHdG, and MDA levels (P = .001). Topical and systemic TQ demonstrated significant advantages in accelerating the wound healing process while also enhancing antioxidant defenses and reducing oxidative damage. SJW oil, particularly in topical application, improved epithelialization, and antioxidant status but showed less efficacy in systemic use. AgSD, while effective in reducing oxidative stress, was less successful in promoting wound healing and appeared to delay granulation and fibrosis. Thymoquinone offers superior protective and healing benefits, SJW is effective locally but less so systemically, and AgSD should be used cautiously, potentially combined with antioxidants to mitigate its negative impact on wound healing.en_US
dc.identifier.doi10.1093/jbcr/irae174
dc.identifier.issn1559-047X
dc.identifier.issn1559-0488
dc.identifier.pmid39275846en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1093/jbcr/irae174
dc.identifier.urihttps://hdl.handle.net/11468/29703
dc.identifier.wosWOS:001342391100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofJournal of Burn Care & Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250222
dc.subjectthymoquinoneen_US
dc.subjectexperimental burn wounden_US
dc.subjectSt. John's wort oilen_US
dc.subjectsilver sulfadiazineen_US
dc.titleComparison of the Effectiveness of Thymoquinone, St. John Wort Oil and Silver Sulfadiazine in Experimental Burn Woundsen_US
dc.typeArticleen_US

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