Effects of Polymeric Zinc Propylen-Bis-Dithiocarbamate (Propineb) on Nasal Mucosa in Rats

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dc.contributor.authorSamanci, Baver
dc.contributor.authorArslan, Eda
dc.contributor.authorSamanci, Seyla Bolukbasi
dc.contributor.authorCaypinar, Basak
dc.contributor.authorDeveci, Engin
dc.contributor.authorSoker, Sevda
dc.contributor.authorSeker, Ugur
dc.date.accessioned2024-04-24T17:24:10Z
dc.date.available2024-04-24T17:24:10Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe objective of this study was to evaluate the histopathologic and immunohistochemical effects of propineb on rat nasal mucosa. Twenty adult Sprague-Dawley rats weighing 180-220 g, were used as experimental animals. The rats were divided into propineb and control groups. The control group received distilled water with spray at the same time period. The experiment was terminated after three weeks. In each case, sections of the nosewere taken. In experimental group, microscopic examination of nasal respiratory mucosa revealed that degenerative changes in epithelium were observed in sections of propineb-treated group. There were also leukocyte infiltration and vascular dilatation detected in the connective tissue. We detected CD34-immunoreactive mononuclear cells and endothel cells in the lamina propria of propineb group. In propineb group compared to the control group, the respiratory epithelium, goblet and basal cell nuclei were stained positive for PCNA. Propineb inhalation may be irritating to the nasal mucosa.en_US
dc.identifier.doi10.4067/S0717-95022016000100013
dc.identifier.endpage89en_US
dc.identifier.issn0717-9502
dc.identifier.issn0717-9367
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84966667719
dc.identifier.scopusqualityQ3
dc.identifier.startpage85en_US
dc.identifier.urihttps://doi.org/10.4067/S0717-95022016000100013
dc.identifier.urihttps://hdl.handle.net/11468/19490
dc.identifier.volume34en_US
dc.identifier.wosWOS:000375223700013
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherSoc Chilena Anatomiaen_US
dc.relation.ispartofInternational Journal of Morphology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPropineben_US
dc.subjectNasal Mucosaen_US
dc.subjectProliferating Cell Nuclear Antigen (Pcna)en_US
dc.subjectCd34en_US
dc.titleEffects of Polymeric Zinc Propylen-Bis-Dithiocarbamate (Propineb) on Nasal Mucosa in Ratsen_US
dc.titleEffects of Polymeric Zinc Propylen-Bis-Dithiocarbamate (Propineb) on Nasal Mucosa in Rats
dc.typeArticleen_US

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