IMMUNOLOCALIZATION OF HOXA11 AND HLX PROTEINS IN COW PLACENTA DURING PREGNANCY

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dc.contributor.authorTopaloglu, Ugur
dc.contributor.authorKetani, Muzaffer Aydin
dc.contributor.authorAkbalik, Mehmet Erdem
dc.contributor.authorSagsoz, Hakan
dc.contributor.authorSaruhan, Berna Guney
dc.contributor.authorBayram, Bayram
dc.date.accessioned2024-04-24T17:20:23Z
dc.date.available2024-04-24T17:20:23Z
dc.date.issued2022
dc.departmentDicle Üniversitesien_US
dc.description.abstractIn addition to its many functions, the placenta is characterized by the intensity and characteristics of its hormonal functions. It has been reported that the development and vascularization of the placenta with normal fetal growth is regulated by many factors such as growth factors, transcriptional factors, and homeobox proteins. This study was conducted to deter-mine the distribution and possible physiological roles of HOXA11 and HLX in the uterus and placenta of pregnant cows. In this study, 27 pregnant Holstein breed cow uteri and placentas obtained from private slaughterhouses were used as tissue samples. In order to determine the pregnancy period of the obtained uterus, the ages of the fetuses were calculated according to the age calculation formula. The uteri were classified under three different groups as the first (69-89 days), second (99-178 days), and third (190-269 days) periods of pregnancy so that there are 9 animals in each group. Tissue samples were then sub-jected to immunohistochemistryto demonstrate the presence of HOXA11 and HLX proteins. It was observed that HOXA11 and HLX immunoreactions occurred prominently in the luminal and glandular epithelial cells of the uterus during pregnancy, and the maternal epithelial cells of the placenta and UTC and TGC/BNCs. In addition, it was determined that HOXA11 immunore-action also formed in some vascular endothelial cells. Immunohistochemical findings in this study suggested that Hoxa11 and HLX may affect the proliferation and differentiation of cells in the uterus and placenta during pregnancy in cows, and that these proteins may contribute to normal uterine physiology, placentation formation, and continuity of pregnancy in cows.en_US
dc.description.sponsorshipscientific research projects commission of Dicle University [VETERINER.19.004]en_US
dc.description.sponsorshipThis study is based on a project numbered as,'VETERINER.19.004, which is supported by the scientific research projects commission of Dicle University.en_US
dc.identifier.doi10.26873/SVR-1347-2022
dc.identifier.endpage111en_US
dc.identifier.issn1580-4003
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85137197037
dc.identifier.scopusqualityQ4
dc.identifier.startpage99en_US
dc.identifier.urihttps://doi.org/10.26873/SVR-1347-2022
dc.identifier.urihttps://hdl.handle.net/11468/19003
dc.identifier.volume59en_US
dc.identifier.wosWOS:000835857000003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherUniv Ljubljana, Veterinary Facultyen_US
dc.relation.ispartofSlovenian Veterinary Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHox Proteinsen_US
dc.subjectHoxa11en_US
dc.subjectHlxen_US
dc.subjectPlacentaen_US
dc.titleIMMUNOLOCALIZATION OF HOXA11 AND HLX PROTEINS IN COW PLACENTA DURING PREGNANCYen_US
dc.titleIMMUNOLOCALIZATION OF HOXA11 AND HLX PROTEINS IN COW PLACENTA DURING PREGNANCY
dc.typeArticleen_US

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