Exploring the Potential of Psephellus huber-Marathi (Wagenitz) Wagenitz: A Comprehensive UHPLC-MS/MS Analysis of Phytochemical Composition and Evaluation of Antioxidant, Antimicrobial, and Antiproliferative Activities

Basit Öğe Kaydı
dc.authoridAKMAN, Tugrul Cagri/0000-0002-5439-950X
dc.authoridaydin, ali/0000-0002-9550-9111
dc.authoridAksit, Zeynep/0000-0002-0349-0223
dc.authoridYILMAZ, Mustafa Abdullah/0000-0002-4090-7227
dc.contributor.authorAkman, Tugrul Cagri
dc.contributor.authorSimsek, Samed
dc.contributor.authorAksit, Zeynep
dc.contributor.authorAydin, Ali
dc.contributor.authorYilmaz, Mustafa Abdullah
dc.date.accessioned2025-02-22T14:08:46Z
dc.date.available2025-02-22T14:08:46Z
dc.date.issued2024
dc.departmentDicle Üniversitesien_US
dc.description.abstractPsephellus huber-morathii (PH) is an endemic species in the Eastern Anatolia Region. In this study, besides the biological activities of the 70% methanol extract of PH, its comprehensive phytochemical composition was investigated. The phenolic composition of the PH extract was analyzed using the UHPLC-MS/MS method. To evaluate its antimicrobial characteristics, the microdilution technique was employed. The antioxidant capabilities and total phenolic and flavonoid contents of the extract were determined using the spectrophotometer. Additionally, the effects of the extracts on cell proliferation and NCI-60 survival parameter values were assessed using the MTT assay. Quinic acid and chlorogenic acid were major compounds. The extract showed high antioxidant activity in DPPH (IC50:13.9 +/- 0.4 jig mL-1) and FRAP (61.3 +/- 2.3 mg TE g extract-1) methods. The total phenolic and flavonoid contents of the extract were found as 52.2 +/- 1.9 mg GAE g extract-1 and 28.6 +/- 0.9 mg QE g extract-1, respectively. Discussion: The extract showed low antiproliferative activity against normal lung and retinal cell lines, promising anticancer effects on gynecological and colon cancer cells, and moderate antimicrobial activity against Bacillus cereus and Enterococcus faecium. The study demonstrated the medicinal potential and value of PH extract against infectious diseases and cancer.en_US
dc.description.sponsorshipACKNOWLEDGMENT The authors thank Dr. Huseyin AKST and Prof. Dr. Ali Kandemir for the collection and taxonomic description of the plant samples.en_US
dc.identifier.doi10.18016/ksutarimdoga.vi.1339345
dc.identifier.endpage792en_US
dc.identifier.issn2619-9149
dc.identifier.issue4en_US
dc.identifier.startpage782en_US
dc.identifier.trdizinid1257794en_US
dc.identifier.urihttps://doi.org/10.18016/ksutarimdoga.vi.1339345
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1257794
dc.identifier.urihttps://hdl.handle.net/11468/29627
dc.identifier.volume27en_US
dc.identifier.wosWOS:001283205500005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.publisherKahramanmaras Sutcu Imam Univ Rektorluguen_US
dc.relation.ispartofKsu Tarim Ve Doga Dergisi-Ksu Journal of Agriculture and Natureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_WOS_20250222
dc.subjectPsephellus huber-Marathi Antimicrobial Antioxidant Antiproliferative LC-MS/MSen_US
dc.titleExploring the Potential of Psephellus huber-Marathi (Wagenitz) Wagenitz: A Comprehensive UHPLC-MS/MS Analysis of Phytochemical Composition and Evaluation of Antioxidant, Antimicrobial, and Antiproliferative Activitiesen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu