The role of FLT3-ITD and CCAAT-enhancer-binding protein alpha mutations on prognosis of acute lymphoblastic leukaemia in Turkish patients

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dc.authorid0000-0001-8463-2723en_US
dc.authorid0000-0001-5673-8408en_US
dc.authorid0000-0002-9232-5982en_US
dc.contributor.authorUluca, Ü.
dc.contributor.authorSöker, M.
dc.contributor.authorAyyıldız, M. Orhan
dc.contributor.authorYurt, M.
dc.contributor.authorŞen, V.
dc.contributor.authorYel, S.
dc.contributor.authorGüneş, A.
dc.contributor.authorCoşkun, S.
dc.contributor.authorTan, İ.
dc.contributor.authorŞahin, C.
dc.date.accessioned2023-04-07T07:11:41Z
dc.date.available2023-04-07T07:11:41Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractBackground: Acute lymphoblastic leukaemia (ALL) is the most common malignancy in childhood. Although some prognostic factors have been defined to date, the estimation of prognosis is currently not perfect. Previous studies had shown an association of FLT3 with poor prognosis and CCAAT-enhancer-binding protein a (CEBPA) mutation with the development of acute myeloid leukaemia (AML). Here, we aimed to evaluate the prognostic value of FLT3-ITD and CEBPA mutations in ALL. Methods: Sixty-one patients with ALL were included in the study. The patients were divided into three risk groups according to BFM risk classification. All of the patients were examined for FLT3-ITD mutations and 45 of them for CEBPA mutations. Mutation positive and negative patients were compared in terms of their risk groups, translocations and cell lineage. The clinical courses of the patients were appraised. Results: FLT3-ITD mutation was detected in 3 of the 61 patients, and CEBPA mutations were detected in 11 of the 45 patients. The incidence of established prognostic indicators including BFM risk classification, t(9; 22); BCR-ABL, t(1; 19); E2A-PBX1, t(12; 21); TEL-AML1, t(4; 11); MLL-AF4 were similar between FLT3-ITD and CEBPA positive and negative patients. A patient with an FLT3-ITD mutation was very susceptible to pancytopenia after maintenance treatment and two other patients with FLT3-ITD mutations were more prone to febrile neutropenia. Conclusion: Our results suggested that CEBPA or FLT3-ITD mutations might not be related to ALL prognosis in the sampled Turkish patients. However; FLT3-ITD mutation might have an influence on the response of bone marrow to chemotherapy.en_US
dc.identifier.citationUluca, Ü., Söker, M., Ayyıldız, M.O., Yurt, M., Şen, V., Yel, S. ve diğerleri (2022). The role of FLT3-ITD and CCAAT-enhancer-binding protein alpha mutations on prognosis of acute lymphoblastic leukaemia in Turkish patients. West Indian Medical Journal, 69(7), 494-498.en_US
dc.identifier.endpage498en_US
dc.identifier.issn0043-3144
dc.identifier.issn2309-5830
dc.identifier.issue7en_US
dc.identifier.scopusScopusIdYok
dc.identifier.scopusqualityQ4
dc.identifier.startpage494en_US
dc.identifier.urihttps://www.mona.uwi.edu/fms/wimj/article/2623
dc.identifier.urihttps://hdl.handle.net/11468/11635
dc.identifier.volume19en_US
dc.identifier.wosWOS:000794032100007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorUluca, Ü.
dc.institutionauthorSöker, Murat
dc.institutionauthorAyyıldız, M. Orhan
dc.institutionauthorYurt, M.
dc.institutionauthorŞen, Velat
dc.institutionauthorYel, S.
dc.institutionauthorGüneş, A.
dc.institutionauthorCoşkun, S.
dc.institutionauthorTan, İ.
dc.institutionauthorŞahin, C.
dc.language.isoenen_US
dc.publisherUniv West Indies Faculty Medical Sciencesen_US
dc.relation.ispartofWest Indian Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute lymphoblastic leukaemiaen_US
dc.subjectCCAAT enhancer binding protein alphaen_US
dc.subjectFLT3en_US
dc.subjectMutationen_US
dc.subjectPrognosisen_US
dc.titleThe role of FLT3-ITD and CCAAT-enhancer-binding protein alpha mutations on prognosis of acute lymphoblastic leukaemia in Turkish patientsen_US
dc.titleThe role of FLT3-ITD and CCAAT-enhancer-binding protein alpha mutations on prognosis of acute lymphoblastic leukaemia in Turkish patients
dc.typeArticleen_US

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