Effects of Potentilla fulgens as a Prophylactic Agent for Ischemia/Reperfusion Injury in the Rat Ovary

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dc.contributor.authorTogrul, Cihan
dc.contributor.authorBalsak, Deniz
dc.contributor.authorEkinci, Cenap
dc.contributor.authorSeckin, Kerem Doga
dc.contributor.authorEkinci, Aysun
dc.contributor.authorTahaoglu, Ali Emre
dc.contributor.authorBademkiran, Hanefi
dc.date.accessioned2024-04-24T17:49:53Z
dc.date.available2024-04-24T17:49:53Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: To investigate the effects of Potentilla fulgens as a prophylactic agent on ischemia/reperfusion (I/R) injury in the rat ovary. STUDY DESIGN: A total of 32 Wistar rats were divided into 4 equal groups: (I) sham, (II) ischemia, (III) ischemia+reperfusion, and (IV) I/R+Potentilla fulgens. In groups I and II, ovary torsion was not performed and no drug was administered. In group III, 1 hour of ischemia and 2 hours of reperfusion were performed and no drug was given. Group IV received 400 mg/kg/day Potentilla fulgens intraperitoneally 5 days before I/R injury. RESULTS: The detorsion group showed preantral ovarian follicles and corpus luteum around the blood vessels and positive expression of vascular endothelial growth factor (VEGF). In the Potentilla fulgens group (IV) the stromal vascular endothelium with weak expression of VEGF was detected in small areas, and the ovarian follicles and the corpus luteum showed negative expression of VEGF. In the detorsion group the theca cells and apoptotic cells in preantral follicles showed positive expression of E-cadherin in the ovarian surface epithelium. Moreover, the E-cadherin expression was found to be positive in terms of follicular development, theca cells, granulosa cells, and corpus luteum. Potentilla fulgens, given after ischemic injury and apoptosis, was seen to decrease the effect of Bcl-2 expression. CONCLUSION: These results provide compelling evidence that the expression of E-cadherin in the ovary is an important component of ovarian function.en_US
dc.identifier.endpage316en_US
dc.identifier.issn0884-6812
dc.identifier.issue5en_US
dc.identifier.pmid26856116
dc.identifier.startpage310en_US
dc.identifier.urihttps://hdl.handle.net/11468/23063
dc.identifier.volume37en_US
dc.identifier.wosWOS:000367870000005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSci Printers & Publ Incen_US
dc.relation.ispartofAnalytical and Quantitative Cytopathology and Histopathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectE-Cadherinen_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectOvarian Torsionen_US
dc.subjectOvaryen_US
dc.subjectReperfusion Damageen_US
dc.subjectReperfusion Injuryen_US
dc.subjectVascular Endothelial Growth Factoren_US
dc.subjectVegfen_US
dc.titleEffects of Potentilla fulgens as a Prophylactic Agent for Ischemia/Reperfusion Injury in the Rat Ovaryen_US
dc.titleEffects of Potentilla fulgens as a Prophylactic Agent for Ischemia/Reperfusion Injury in the Rat Ovary
dc.typeArticleen_US

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