PLASMA D-DIMER LEVELS IN ACUTE ISCHEMIC STROKE: ASSOCIATION WITH MORTALITY, STROKE TYPE AND PROGNOSIS
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Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Nobel Ilac
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: The purpose of this study is to examine the correlation between mortality, stroke sub-types, neurological disability and D-Dimer values measured before a specific treatment is given to patients in the emergency department. Material and Method: In the first 24 hours after stroke symptoms started and before anticoagulant treatment started, the serum D-Dimer levels of every patient were examined. The stroke sub-type of every patient was determined according to TOAST criteria and clinical classification was made according to the Oxfordshire Community Stroke Project (OCSP). The Rankin scale was used to determine the neurological disability of the surviving patients. Results: Ninety one patients were included in the study. There was a significant difference between the D-Dimer levels of patients who died and who survived (4.50+2.80 and 1.39+1.36 ng/ml respectively, p=0.003). According to the TOAST criteria, average D-dimer levels of cardioembolic and atherothrombotic stroke patients were higher than the control group. (4.35 +/- 3.03/ 3.11 +/- 1.69 and 0.43 +/- 0.26 respectively, p=0.000). According to OCSP classification, average D-dimer levels of patients with total anterior circulation infract (TOCI) and partial anterior circulation infract (PACI) were higher than the control group, (3.67 +/- 2.14, 4 +/- 3.03 and 0.43 +/- 0.26, respectively, p=0.000). The evaluation of surviving stroke patients in terms of neurological disability revealed that average D-dimer levels of patients with serious neurological disability (Rankin score=3-5) were higher than patients with slight neurological disability (Rankin score=0 and Rankin score=12), (2.85 +/- 1.69; 0.79 +/- 0.56; 0.81 +/- 0.44 respectively, p=0.000). Conclusion: We reached the conclusion that D-dimer levels in the acute period can be a leading factor for clinicians in predicting the direct results of cerebral infarct and deciding the type of treatment.
Açıklama
Anahtar Kelimeler
Stroke, D-Dimer, Mortality, Neurological Disability
Kaynak
Nobel Medicus
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
6
Sayı
2
