Comparison of serum and salivary alpha-fetoprotein levels in pregnancies complicated with neural tube defects

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dc.authorid0000-0002-3285-9990en_US
dc.contributor.authorKaraçor, Talip
dc.contributor.authorBülbül, Mehmet
dc.contributor.authorNacar, Mehmet Can
dc.contributor.authorKırıcı, Pınar
dc.contributor.authorÖnderci, Muhittin
dc.contributor.authorPeker, Nurullah
dc.contributor.authorSak, Sibel
dc.date.accessioned2021-09-06T10:32:57Z
dc.date.available2021-09-06T10:32:57Z
dc.date.issued2020en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalıen_US
dc.descriptionWOS:000576583500004
dc.description.abstractObjective: To compare the serum and salivary values of alpha-fetoprotein (AFP) used in screening neural tube defects (NTD) during pregnancy. To investigate whether saliva can be used instead of serum in NTD screening. Method: The study was conducted between May 2018 - November 2019 at Adıyaman University. The study included 41 pregnant women complicated by NTD and 44 healthy pregnant women. Three ml venous blood and 2 ml saliva samples were taken from both groups. Serum and saliva samples were not diluted. AFP concentration was measured at 450 nm by using commercially available enzyme-linked immunoassay. The intra‐ , and inter- test assay coefficients (CVs) of the kit were <8% and <10%, respectively. SPSS 21 program was used for data analysis. Mann-Whitney Test was used for the analysis of continuously changing parameters. The correlation coefficient was calculated by Spearman test. A p value of less than 0.05 was accepted for statistical significance. Results: When serum and salivary AFP values were compared between the two groups, the AFP values were found to be higher in both NTD group samples (p<0.001, p<0.001). In both groups, correlation analysis for serum and salivary AFP values showed a strong positive correlation (r=0.730, p<0.001). When the cut-off value for serum AFP is taken as 0.26, NTD can be determined with 100% sensitivity and 90% specificity (AUC: 0.932, p<0.001). When the cut-off value for salivary AFP is taken as 0.034, it can detect NTD with 95% sensitivity and 92% specificity (AUC: 1.00, p<0.001). Conclusion: Salivary and serum AFP values showed strong positive correlation between themselves. We believe that saliva can be used in NTD screening performed by AFP measurement.en_US
dc.identifier.citationKaraçor, T., Bülbül, M., Nacar, M.C., Kırıcı, P., Önderci, M., Peker, N. ve diğerleri. (2020). Comparison of serum and salivary alpha-fetoprotein levels in pregnancies complicated with neural tube defects. Medical Journal of Bakirkoy, 16(3), 212-217.en_US
dc.identifier.doi10.5222/BMJ.2020.03164
dc.identifier.endpage217en_US
dc.identifier.issn1305-9319
dc.identifier.issn1305-9327
dc.identifier.issue3en_US
dc.identifier.startpage212en_US
dc.identifier.trdizinid412034
dc.identifier.urihttp://cms.galenos.com.tr/Uploads/Article_47727/BTD-16-212-En.pdf
dc.identifier.urihttps://hdl.handle.net/11468/7441
dc.identifier.volume16en_US
dc.identifier.wosWOS:000576583500004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorPeker, Nurullah
dc.language.isoenen_US
dc.publisherYerküre Tanıtım & Yayıncılık Hizmetleri A.Ş.en_US
dc.relation.ispartofMedical Journal of Bakirkoy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNeural tube defecten_US
dc.subjectAlpha-fetoproteinen_US
dc.subjectSalivaen_US
dc.subjectAnomalyen_US
dc.subjectScreening testen_US
dc.titleComparison of serum and salivary alpha-fetoprotein levels in pregnancies complicated with neural tube defectsen_US
dc.titleComparison of serum and salivary alpha-fetoprotein levels in pregnancies complicated with neural tube defects
dc.typeArticleen_US

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