The Prevalence of MEFV Gene Mutations in Rheumatoid Arthritis Patients Inhabiting the Van Province and Surroundings

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dc.contributor.authorOzkol, Halil
dc.contributor.authorYildirim, Ibrahim Halil
dc.contributor.authorTuluce, Yasin
dc.contributor.authorEdiz, Levent
dc.contributor.authorDelen, Veysel
dc.contributor.authorGulcu, Elif
dc.date.accessioned2024-04-24T17:27:30Z
dc.date.available2024-04-24T17:27:30Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: An inhibitory protein of inflammation pyrin/marenostrin is encoded by the Mediterranean fever (MEFV) gene. Mutations of this gene are known to cause familial Mediterranean fever (FMF) disease. A relation between mutations of the MEFV gene and rheumatic diseases was also suggested. The aim of the present study was to investigate the frequency of four common mutations of the MEFV gene in 110 rheumatoid arthritis (RA) patients and 98 healthy controls (HC) inhabiting a region of eastern Turkey. Material and Methods: DNA extraction was realized by salting out method from peripheral blood lymphocytes of all subjects included in the study. Polymerase chain reactions (PCR) amplification of exon 10 was performed by the appropriate primers, and single-nucleotide polymorphisms (SNPs) were detected by specific restriction endonucleases recognizing the mutational DNA or wild-type DNA regions. Results: Mutation frequency of RA patients was higher than in HC, but this result was not statistically significant (p>0.05). Conclusion: The MEFV mutation rate of RA patients living in eastern Turkey was not significantly different from HC. Further studies are needed to investigate other gene mutations that may affect RA etiopathogenesis.en_US
dc.description.sponsorshipUniversity of Yuzuncu Yil Grant Commission [YYU-BAP-2010-TF-B020]en_US
dc.description.sponsorshipThe authors are grateful to the University of Yuzuncu Yil Grant Commission for providing financial assistance during the tenure of research numbered with YYU-BAP-2010-TF-B020.en_US
dc.identifier.doi10.5152/tftrd.2014.46244
dc.identifier.endpage21en_US
dc.identifier.issn1302-0234
dc.identifier.issn1308-6316
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84899751162
dc.identifier.scopusqualityN/A
dc.identifier.startpage17en_US
dc.identifier.urihttps://doi.org/10.5152/tftrd.2014.46244
dc.identifier.urihttps://hdl.handle.net/11468/19996
dc.identifier.volume60en_US
dc.identifier.wosWOS:000340590100004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherBaycinar Medical Publ-Baycinar Tibbi Yayinciliken_US
dc.relation.ispartofTurkiye Fiziksel Tip Ve Rehabilitasyon Dergisi-Turkish Journal of Physical Medicine and Rehabilitation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRheumatoid Arthritisen_US
dc.subjectMediterranean Feveren_US
dc.subjectPyrinen_US
dc.subjectSingle-Nucleotideen_US
dc.subjectPolymorphismsen_US
dc.titleThe Prevalence of MEFV Gene Mutations in Rheumatoid Arthritis Patients Inhabiting the Van Province and Surroundingsen_US
dc.titleThe Prevalence of MEFV Gene Mutations in Rheumatoid Arthritis Patients Inhabiting the Van Province and Surroundings
dc.typeArticleen_US

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