Pulse Methylprednisolone-Induced Sinus Bradycardia: A Case Report

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dc.contributor.authorBeyler, Ozlem
dc.contributor.authorDemir, Cengiz
dc.date.accessioned2024-04-24T17:28:12Z
dc.date.available2024-04-24T17:28:12Z
dc.date.issued2023
dc.departmentDicle Üniversitesien_US
dc.description.abstractCorticosteroids have a wide range of uses. The most common adverse side effects of high-dose pulse steroids are hyperglycemia, gastrointestinal intolerance, and psychiatric symptoms. Cardiac arrhythmias have been reported in patients who receive high- dose steroid therapy. Bradycardia is a rare adverse side effect of pulse steroid therapy. We present the case of a 57-year-old male patient who developed symptomatic sinus bradycardia after he received pulse methylprednisolone therapy as treatment for graft-versus-host disease. The patient's pulse steroid therapy was discontinued, and the dose of methylprednisolone was reduced to 100 mg/ day. He was treated conservatively and with close observation; the patient's heart rate increased to 68 beats/min after 1 day, and then to 78 beats/min. The diagnosis of methylprednisolone-induced bradycardia was made after exclusion of other common etiologies of sinus bradycardia. This case report demonstrates the importance of careful cardiovascular monitoring in patients who receive high-dose methylprednisolone because of dose-related cardiovascular risks.en_US
dc.identifier.doi10.6002/ect.2023.0095
dc.identifier.endpage924en_US
dc.identifier.issn1304-0855
dc.identifier.issn2146-8427
dc.identifier.issue11en_US
dc.identifier.pmid38140936
dc.identifier.startpage921en_US
dc.identifier.urihttps://doi.org/10.6002/ect.2023.0095
dc.identifier.urihttps://hdl.handle.net/11468/20363
dc.identifier.volume21en_US
dc.identifier.wosWOS:001167682400011
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherBaskent Univen_US
dc.relation.ispartofExperimental and Clinical Transplantation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCardiovascular Risken_US
dc.subjectGraft-Versus-Host Diseaseen_US
dc.subjectHigh-Dose Steroid Therapyen_US
dc.subjectPulse Therapyen_US
dc.titlePulse Methylprednisolone-Induced Sinus Bradycardia: A Case Reporten_US
dc.titlePulse Methylprednisolone-Induced Sinus Bradycardia: A Case Report
dc.typeArticleen_US

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