Complexation and transport of amino acid esters and their salts with synthesised chiral novel aza crown ether derivatives
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Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The syntheses of four aza-15-crown-5 ethers bearing phenyl and phenoxymethyl moieties attached to a stereogenic centre on the crown ring were achieved. Macrocycles have exhibited strong binding ability (K-a=5364-12,969M(-1)) and modest enantiomeric discrimination towards the enantiomers of amino acid methyl ester salts by UV titration method in CHCl3 at 25 degrees C. Computer modelling results supported experimental data providing a detailed understanding of the molecular recognition mode between hosts and guests and the likely binding sites involved. Macrocycles were used for chiral discrimination of amino acids in their zwitterionic forms or as potassium and sodium salts in transport experiments across a bulk chloroform membrane with satisfactory selectivity.
Açıklama
Anahtar Kelimeler
Chiral Amino Alcohols, Aza Crown Ethers, Enantiomeric Recognition, Transport Of Amino Acids
Kaynak
Supramolecular Chemistry
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
26
Sayı
5-6
