Molecularly imprinted cryogel as a pH-responsive delivery system for doxorubicin

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dc.contributor.authorCetin, Kemal
dc.contributor.authorAlkan, Huseyin
dc.contributor.authorBereli, Nilay
dc.contributor.authorDenizli, Adil
dc.date.accessioned2024-04-24T16:24:55Z
dc.date.available2024-04-24T16:24:55Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractIn this study, implantable and degradable molecularly imprinted cryogel was prepared for pH-responsive delivery of doxorubicin. Cryogel discs were synthesized using amino acid-based functional monomer with HEMA and gelatin. The molecularly imprinted discs were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, degradation and swelling tests. In vitro delivery experiments were carried out in order to examine the effects of medium pH and drug content. The degree of degradation of composite cryogels was found to be 83.45 +/- 1.86% after 56days. The release profiles of DOX from molecularly imprinted cryogel discs exhibit a biphasic delivery. It was observed that an initial burst release step from 0 to 12h was followed by a slower and sustained release. Release rate of DOX from cryogel discs increased in more acidic conditions. Kinetic studies showed that a combination of diffusion and erosion control is mainly responsible from the general release behaviors of molecularly imprinted cryogel discs.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [TUBITAK-BIDEB 2211]en_US
dc.description.sponsorshipKemal Cetin thanks The Scientific and Technological Research Council of Turkey (TUBITAK) for the support by TUBITAK-BIDEB 2211-National Ph.D Scholarship Programme.en_US
dc.identifier.doi10.1080/10601325.2017.1320757
dc.identifier.endpage508en_US
dc.identifier.issn1060-1325
dc.identifier.issn1520-5738
dc.identifier.issue8en_US
dc.identifier.scopus2-s2.0-85023739869en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage502en_US
dc.identifier.urihttps://doi.org/10.1080/10601325.2017.1320757
dc.identifier.urihttps://hdl.handle.net/11468/16897
dc.identifier.volume54en_US
dc.identifier.wosWOS:000405568900002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal of Macromolecular Science Part A-Pure and Applied Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCryogelsen_US
dc.subjectDoxorubicin Deliveryen_US
dc.subjectMolecular Imprintingen_US
dc.subjectPh Responsiveen_US
dc.titleMolecularly imprinted cryogel as a pH-responsive delivery system for doxorubicinen_US
dc.typeArticleen_US

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