Clopidogrel resistance in patients with type 2 Diabetes Mellitus: A comparison between oral antidiabetic agents and insulin

Basit Öğe Kaydı
dc.contributor.authorAriturk, Zuhal
dc.contributor.authorCil, Habib
dc.contributor.authorGunduz, Ercan
dc.contributor.authorYavuz, Celal
dc.contributor.authorKaya, Hasan
dc.contributor.authorErtas, Faruk
dc.contributor.authorOylumlu, Mustafa
dc.date.accessioned2024-04-24T17:33:21Z
dc.date.available2024-04-24T17:33:21Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Clopidogrel resistance has been found in certain patient populations, including patients with acute coronary syndrome, ischemic stroke, patients undergoing percutaneous coronary intervention with a drug-eluting stent, diabetes mellitus, ischemic stroke and stent restenosis. The aim of this study was to assess clopidogrel resistance in diabetic patients taking oral antidiabetic drugs and insulin. Methods and Results: Platelet aggregation was measured after clopidogrel treatment in 101 diabetic patients undergoing percutaneous coronary intervention. Two diabetic patient subpopulations were compared: patients who used insulin (group 1) and patients who used oral antidiabetic agents (group 2). Clopidogrel nonresponders and responders were defined by a relative inhibition of adenosine diphosphate (20 mol/L) induced platelet aggregation of < 10% and >= 30%, respectively. Among group 1 patients, 12.5% were clopidogrel nonresponders and Among group 2 patients, 9.4% were clopidogrel nonresponders. There were no statistical differences found between the two groups (P=0.618). Conclusions: This study demonstrates that there was no significant difference in the clopidogrel resistance between type 2 diabetes mellitus patients taking insulin or oral antidiabetes medication. The clinical implications of this finding are unknown and need to be evaluated in large-scale clinical trials.en_US
dc.identifier.endpage3328en_US
dc.identifier.issn1840-2291
dc.identifier.issue10en_US
dc.identifier.scopus2-s2.0-84871235618
dc.identifier.scopusqualityN/A
dc.identifier.startpage3323en_US
dc.identifier.urihttps://hdl.handle.net/11468/20637
dc.identifier.volume6en_US
dc.identifier.wosWOS:000312158300013
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherDrunpp-Sarajevoen_US
dc.relation.ispartofHealthmed
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectClopidogrelen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectPlateletsen_US
dc.titleClopidogrel resistance in patients with type 2 Diabetes Mellitus: A comparison between oral antidiabetic agents and insulinen_US
dc.titleClopidogrel resistance in patients with type 2 Diabetes Mellitus: A comparison between oral antidiabetic agents and insulin
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu