The role of prenatal steroid and TRH treatment in rats with nitrofen induced diaphragmatic hernia

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dc.contributor.authorÇi?dem M.K.
dc.contributor.authorDokucu A.I.
dc.contributor.authorÖnen A.
dc.contributor.authorOtçu S.
dc.contributor.authorÖztürk H.
dc.contributor.authorDeveci E.
dc.contributor.authorYücesan S.
dc.date.accessioned2024-04-24T17:58:47Z
dc.date.available2024-04-24T17:58:47Z
dc.date.issued2000
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe mortality of congenital diaphragmatic hernia (CDH) is high due to associated pulmonary hypoplasia and pulmonary hypertension. Thus studies aiming to prevent pulmonary hypoplasia in the prenatal period are gaining importance. In this study the role of glucocorticoids and "Thyroid releasing hormone" (TRH) on lung maturation in rats with nitrofen induced CDH is investigated. Ten pregnant Wistar-Albino female rats received nitrofen (100 mg) in two groups on their 9.5 day of pregnancy, while the control group had olive oil administered. In one nitrofen group additionally starting on day 16, glucocorticoids (0, 25 mg/kg betametazon) and TRH (25 ?g/kg) was administered for 5 days. Fetuses were delivered by ceaserean section on the 21st day of gestation and the fetal lungs were histopathologically investigated and DNA analysis and maturation were obtained. Nine fetuses in the control, 14 in the nitrofen and 7 in the treatment group could be investigated. No significant difference was identified in the morphologic evaluation and DNA analysis of the nitrofen and treatment groups. Histopathology revealed hypoplasia that was more prominent in the left lung in both groups. In conclusion the prenatal administration of TRH and glucocorticoids in prevention of nitrofen induced CDH has not been found effective. We believe this may be related to the initiation of treatment on day 16 of gestation.en_US
dc.identifier.endpage57en_US
dc.identifier.issn1016-5142
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-0034487844en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage53en_US
dc.identifier.urihttps://hdl.handle.net/11468/24100
dc.identifier.volume14en_US
dc.indekslendigikaynakScopus
dc.language.isotren_US
dc.relation.ispartofPediatrik Cerrahi Dergisien_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCongenital Diaphragmatic Herniaen_US
dc.subjectFetal Diseaseen_US
dc.subjectFetal Organ Maturityen_US
dc.subjectFetal Therapyen_US
dc.subjectPulmonary Hypertensionen_US
dc.subjectSteroidsen_US
dc.subjectThyroid Hormonesen_US
dc.titleThe role of prenatal steroid and TRH treatment in rats with nitrofen induced diaphragmatic herniaen_US
dc.title.alternativeSiçanlarda nitrofen ile oluşturulan diafragma hernisinde prenatal steroid ve TRH tedavisinin yerien_US
dc.typeNoteen_US

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