Metallobeta-Lactamase Enzymes and Antibiotic Susceptibilities in Strains of Pseudomonas Aeruginosa Isolated from Intensive Care Units in Turkey

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dc.contributor.authorCesur, Salih
dc.contributor.authorYildiz, Eda
dc.contributor.authorIrmak, Hasan
dc.contributor.authorGulay, Zeynep
dc.contributor.authorArslan, Ugur
dc.contributor.authorOzen, Sepin
dc.contributor.authorBayramoglu, Gulcin
dc.date.accessioned2024-04-24T17:27:36Z
dc.date.available2024-04-24T17:27:36Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to determine the frequency of metallobeta-lactamase (MBL) enzyme in Pseudomonas aeruginosa strains resistant to carbapenem (imipenem or/and meropenem) in seven regions of Turkey and to assess the minimal inhibitory concentration (MIC) levels of drugs used in treatment such as colistin, aztreonam, polymyxin B and rifampin. Overall 186 Pseudomonas aeruginosa (P.aeruginosa) strains resistant to carbapenem from 8 provinces (Ankara, Konya, Antalya, Istanbul, izmir, Diyarbakir, Van and Trabzon) representing 7 different geographical regions of Turkey were included in the study. Material and Methods: The presence of MBL in P.aeruginosa strains resistant to carbapenem was investigated by combined disk methods with imipenem and EDTA absorbed imipenem disk. The MBL positivity was determined in the strains. Additionally, susceptibility to aztreonam, colistin, polymyxin B, and rifampin was established by the E-test method. Results: MBL enzyme positivity was detected in 58 out of 186 strains (31.2%). There was statistically significant difference between regions in terms of MBL positivity, with the highest rates in Antalya (52%), and Istanbul (50%) and the lowest in Diyarbakir (6%). Aztreonam sensitivity was detected in 134 (72%) strains; 155 (83.3%) were sensitive to colistin and 148 (79.6%) to polymixine. No strain (0%) was sensitive to rifampin. Conclusion: In conclusion, the overall mean rate of MBL positivity was 31.2%, which is quite high. Therefore, it will be beneficial to confirm the MBL positivity of strains with molecular methods, to review regional antibiotic surveillance data at certain intervals and to share the obtained data with relevant institutions in order to prevent the regional spread of these strains. Thus, it is essential to record and monitor systematically the antibiotic surveillance data.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [SBAG-HD-62]en_US
dc.description.sponsorshipWe are grateful to The Scientific and Technological Research Council of Turkey (TUBITAK) for their support of this project (SBAG-HD-62).en_US
dc.identifier.doi10.5336/medsci.2011-24972
dc.identifier.endpage693en_US
dc.identifier.issn1300-0292
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84857824534en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage687en_US
dc.identifier.urihttps://doi.org/10.5336/medsci.2011-24972
dc.identifier.urihttps://hdl.handle.net/11468/20088
dc.identifier.volume32en_US
dc.identifier.wosWOS:000307199900012
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherOrtadogu Ad Pres & Publ Coen_US
dc.relation.ispartofTurkiye Klinikleri Tip Bilimleri Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPseudomonas Aeruginosaen_US
dc.subjectCarbapenemaseen_US
dc.subjectIntensive Care Unitsen_US
dc.subjectBeta-Lactamaseen_US
dc.titleMetallobeta-Lactamase Enzymes and Antibiotic Susceptibilities in Strains of Pseudomonas Aeruginosa Isolated from Intensive Care Units in Turkeyen_US
dc.typeArticleen_US

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