Classic Kaposi's sarcoma: A review of 156 cases

dc.contributor.authorÇetin, Bülent
dc.contributor.authorAktaş, Bilge
dc.contributor.authorBal, Oznur
dc.contributor.authorAlgin, Efnan
dc.contributor.authorAkman, Tülay
dc.contributor.authorKoral, Lokman
dc.contributor.authorKaplan, Mehmet Ali
dc.contributor.authorUncu, Doğan
dc.contributor.authorÖzet, Ahmet
dc.date.accessioned2022-08-10T07:36:39Z
dc.date.available2022-08-10T07:36:39Z
dc.date.issued2018en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıklar Ana Bilim Dalıen_US
dc.description.abstractBackground: Kaposi's sarcoma (KS) is a reactive, multifocal, multicentric, angiogenic neoplastic proliferation that is thought to originate from endothelial cells that are infected with human herpesvirus-8 (HHV-8). This report examines a cohort of patients with classic Kaposi's sarcoma (KS) evaluated at the national institute of oncology over the 13-year period. Methods: A retrospective analysis of 156 patients with classic KS, between January 2000 and November 2013, was performed. This study focused on the clinical presentation, staging, diagnosis, and treatment of classic KS. Results: One hundred fifty-six patients (median age 69 and 115 male) were enrolled into the study. Median age at diagnosis was 69 (range: 32–95 years). Male/female ratio was 2.80. The most common location was the lower limbs. There were 75 stage I patients (48.1%), 8 stage II patients (22.4%), 31 stage III patients (19.9%) and 15 stage IV patients (9.6%). Surgery was the most common local treatment method (43%). 44 patients (28.2%) received radiotherapy (RT) at diagnosis. Cytotoxic treatment with chemotherapy or interferon-α was administered in 57 patients. Visceral involvement was observed in 10 patients (lung: nine patients, liver: one patient) and bone metastasis occurred in two patients at relapse. Conclusion: This study is one of the largest reported series. Further studies are required and it will be important to standardize the assessment of disease activity and clinical response.en_US
dc.identifier.citationÇetin, B., Aktaş, B., Bal, O., Algin, E., Akman, T., Koral, L. ve diğerleri (2018). Classic Kaposi's sarcoma: A review of 156 cases. Dermatologica Sinica, 36(4), 185-189.en_US
dc.identifier.doi10.1016/j.dsi.2018.06.005
dc.identifier.endpage189en_US
dc.identifier.issn1027-8117
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85049434102
dc.identifier.scopusqualityQ2
dc.identifier.startpage185en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1027811717301933?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/11468/10158
dc.identifier.volume36en_US
dc.identifier.wosWOS:000451077200002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorKaplan, Mehmet Ali
dc.language.isoenen_US
dc.publisherElsevier Ltden_US
dc.relation.ispartofDermatologica Sinica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChemotherapyen_US
dc.subjectClassic Kaposi's sarcomaen_US
dc.subjectRadiotherapyen_US
dc.subjectSurgeryen_US
dc.titleClassic Kaposi's sarcoma: A review of 156 casesen_US
dc.titleClassic Kaposi's sarcoma: A review of 156 cases
dc.typeArticleen_US

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