Investigation of the effect of denosumab and ozone application on bone healing in critical size bone defects

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dc.authorid0000-0003-3642-1109en_US
dc.authorid0000-0002-3280-1430en_US
dc.contributor.authorKeskin, Ersin
dc.contributor.authorKaya, Beyza
dc.contributor.authorAktaş, Ayfer
dc.date.accessioned2025-02-17T06:31:33Z
dc.date.available2025-02-17T06:31:33Z
dc.date.issued2024en_US
dc.departmentDicle Üniversitesi, Diş Hekimliği Fakültesi, Ağız-Diş-Çene Hastalıkları ve Cerrahisi Bölümüen_US
dc.description.abstractAims: In maxillofacial surgery, various drugs are used in order to accelerate the recovery of defects caused by any reason. Several studies have shown that denosumab from bisphosphonate group drugs used in osteoporosis patients has positive effects on new bone formation. In general medicine and dentistry, ozone is in widespread use as an alternative treatment and has positive effects on new bone formation. The aim of this study was to evaluate new bone formation by performing denosumab and ozone on critical-sized rat calvarium defects. Methods: In our study, 40 Sprague Dawley rats were used. Rats were divided into 4 groups. Only grafts were placed in the control group. After applying graft to ozone group (O) and ozone and denosumab (O-D) groups, topical ozone was applied for 15 seconds. Denosumab group (D) and O-D group were injected subcutaneously (s.c) 10 mg/kg Prolia (denosumab) every 4 weeks for 8 weeks. 5 animals from each group at the end of week 4, while the other five animals in the group at the end of 8 weeks after being sacrificed for histopathological examination was performed. The differences between the groups were evaluated by statistical analysis. Results: After histopathological examination, better bone formation was observed in the ozone and denosumab treated groups compared to the control group. There was no statistically significant difference between the groups except for the control group, however, new bone formation was determined in the groups treated with denosumab compared to the ozone group. Conclusion: As a result of our study, we believe that the application of ozone and denosumab has a positive effect on the formation of new bone, but more comprehensive studies on the subject are needed.en_US
dc.identifier.citationKeskin, E., Kaya, B. ve Aktaş, A. (2024). Investigation of the effect of denosumab and ozone application on bone healing in critical size bone defects. Dicle Dental Journal, 25(2), 38-45.en_US
dc.identifier.endpage45en_US
dc.identifier.issn2822-6755
dc.identifier.issue2en_US
dc.identifier.startpage38en_US
dc.identifier.urihttps://dergipark.org.tr/en/pub/dicledentj/issue/85356
dc.identifier.urihttps://hdl.handle.net/11468/29458
dc.identifier.volume25en_US
dc.institutionauthorKaya, Beyza
dc.institutionauthorAktaş, Ayfer
dc.language.isoenen_US
dc.publisherDicle Üniversitesi Diş Hekimliği Fakültesien_US
dc.relation.ispartofDicle Dental Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRaten_US
dc.subjectOzoneen_US
dc.subjectDenosumaben_US
dc.subjectNew bone formationen_US
dc.titleInvestigation of the effect of denosumab and ozone application on bone healing in critical size bone defectsen_US
dc.titleInvestigation of the effect of denosumab and ozone application on bone healing in critical size bone defects
dc.typeArticleen_US

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