Investigation of the effect of denosumab and ozone application on bone healing in critical size bone defects
Yükleniyor...
Tarih
2024
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Dicle Üniversitesi Diş Hekimliği Fakültesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aims: In maxillofacial surgery, various drugs are used in order to accelerate the recovery of defects caused by any reason.
Several studies have shown that denosumab from bisphosphonate group drugs used in osteoporosis patients has positive
effects on new bone formation. In general medicine and dentistry, ozone is in widespread use as an alternative treatment
and has positive effects on new bone formation. The aim of this study was to evaluate new bone formation by performing
denosumab and ozone on critical-sized rat calvarium defects.
Methods: In our study, 40 Sprague Dawley rats were used. Rats were divided into 4 groups. Only grafts were placed in the
control group. After applying graft to ozone group (O) and ozone and denosumab (O-D) groups, topical ozone was applied
for 15 seconds. Denosumab group (D) and O-D group were injected subcutaneously (s.c) 10 mg/kg Prolia (denosumab) every
4 weeks for 8 weeks. 5 animals from each group at the end of week 4, while the other five animals in the group at the end of
8 weeks after being sacrificed for histopathological examination was performed. The differences between the groups were
evaluated by statistical analysis.
Results: After histopathological examination, better bone formation was observed in the ozone and denosumab treated groups
compared to the control group. There was no statistically significant difference between the groups except for the control
group, however, new bone formation was determined in the groups treated with denosumab compared to the ozone group.
Conclusion: As a result of our study, we believe that the application of ozone and denosumab has a positive effect on the
formation of new bone, but more comprehensive studies on the subject are needed.
Açıklama
Anahtar Kelimeler
Rat, Ozone, Denosumab, New bone formation
Kaynak
Dicle Dental Journal
WoS Q Değeri
Scopus Q Değeri
Cilt
25
Sayı
2
Künye
Keskin, E., Kaya, B. ve Aktaş, A. (2024). Investigation of the effect of denosumab and ozone application on bone healing in critical size bone defects. Dicle Dental Journal, 25(2), 38-45.
