Asymmetric transfer hydrogenation of acetophenone derivatives with novel chiral phosphinite based ?6-p-cymene/ruthenium(II) catalysts

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dc.contributor.authorAydemir, Murat
dc.contributor.authorMeric, Nermin
dc.contributor.authorBaysal, Akin
dc.contributor.authorTurgut, Yilmaz
dc.contributor.authorKayan, Cezmi
dc.contributor.authorSeker, Sevil
dc.contributor.authorTogrul, Mahmut
dc.date.accessioned2024-04-24T16:15:14Z
dc.date.available2024-04-24T16:15:14Z
dc.date.issued2011
dc.departmentDicle Üniversitesien_US
dc.description.abstractEnantioselective reduction of prochiral ketones to optically active secondary alcohols is an important subject in synthetic organic chemistry because the resulting chiral alcohols are extremely useful, biologically active compounds. The new chiral ligands (2R)-2-[benzyl{(2-((diphenylphosphanyl)oxy)ethyl)}amino]butyldiphenylphosphinite, 1 and (2R)-2-[benzyl{(2-((dicyclohexylphosphanyl)oxy)ethyl)}amino]butyldicyclohexylphosphinite, 2 and the corresponding ruthenium(II) complexes 3 and 4 have been prepared. The structures of these complexes have been elucidated by a combination of multinuclear NMR spectroscopy, IR spectroscopy and elemental analysis. P-31-{H-1} NMR, DEPT, H-1-C-13 HETCOR or H-1-H-1 COSY correlation experiments were used to confirm the spectral assignments. These ruthenium(II) ephosphinite complexes have been used as catalysts for the asymmetric transfer hydrogenation of acetophenone derivatives. Under optimized conditions, aromatic ketones were reduced in good conversions and in moderate to good enantioselectivities (up to 85% ee). (C) 2011 Elsevier B. V. All rights reserved.en_US
dc.description.sponsorshipDicle University [DUBAP-07-01-22]en_US
dc.description.sponsorshipPartial support from Dicle University (Project number: DUBAP-07-01-22) is gratefully acknowledged.en_US
dc.identifier.doi10.1016/j.jorganchem.2010.12.027
dc.identifier.endpage1546en_US
dc.identifier.issn0022-328X
dc.identifier.issue8en_US
dc.identifier.scopus2-s2.0-79953662246
dc.identifier.scopusqualityQ2
dc.identifier.startpage1541en_US
dc.identifier.urihttps://doi.org/10.1016/j.jorganchem.2010.12.027
dc.identifier.urihttps://hdl.handle.net/11468/15720
dc.identifier.volume696en_US
dc.identifier.wosWOS:000289072300006
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherElsevier Science Saen_US
dc.relation.ispartofJournal of Organometallic Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAsymmetric Transfer Hydrogenationen_US
dc.subjectHomogeneous Catalysisen_US
dc.subjectChiral Phosphinite Ligandsen_US
dc.subjectRuthenium(Ii) Complexesen_US
dc.titleAsymmetric transfer hydrogenation of acetophenone derivatives with novel chiral phosphinite based ?6-p-cymene/ruthenium(II) catalystsen_US
dc.titleAsymmetric transfer hydrogenation of acetophenone derivatives with novel chiral phosphinite based ?6-p-cymene/ruthenium(II) catalysts
dc.typeArticleen_US

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