WIPI-2 protein expression increases in the placentas of patients with preeclampsia

Basit Öğe Kaydı
dc.contributor.authorAşır F.
dc.contributor.authorOğlak S.C.
dc.contributor.authorAğaçayak E.
dc.contributor.authorAkkuş M.
dc.contributor.authorDeveci E.
dc.date.accessioned2024-04-24T17:58:30Z
dc.date.available2024-04-24T17:58:30Z
dc.date.issued2023
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: This study aimed to investigate WD-repeat protein interacting with phosphoinositides-2 (WIPI-2) protein expression in the placentas of preeclamptic patients by immunohistochemical method. Methods: Placentas of 25 healthy normotensive women and 25 women with preeclampsia were enrolled in this study. Placental samples were fixed in zinc-formalin and further processed for paraffin wax tissue embedding. Demographic and laboratory parameters of patients were recor-ded. WIPI-2 immune activity was analyzed in the placental section with immunohistochemistry. Results: There was a high number of placental lesions such as vascular congestion, fibrinoid accumulation, hemorrhage, and villous degene-ration in preeclamptic placentas compared to normotensive placentas. WIPI-2 immune reaction was significantly increased in preeclamptic placentas when compared to normotensive placentas. WIPI-2 expression was predominantly observed in the placental villi. Conclusion: Autophagy is a process that occurs in normal placentation. However, dysfunction in the autophagic mechanism is observed in the placentas of preeclamptic patients and WIPI-2 expression could be used to show autophagy. © 2023 Perinatal Medicine Foundation.en_US
dc.identifier.doi10.59215/prn.23.0313007
dc.identifier.endpage223en_US
dc.identifier.issn1305-3124
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85189019805
dc.identifier.scopusqualityQ4
dc.identifier.startpage219en_US
dc.identifier.urihttps://doi.org/10.59215/prn.23.0313007
dc.identifier.urihttps://hdl.handle.net/11468/23955
dc.identifier.volume31en_US
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherPerinatal Medicine Foundationen_US
dc.relation.ispartofPerinatal Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAutophagyen_US
dc.subjectEndothelial Dysfunctionen_US
dc.subjectHypoxiaen_US
dc.subjectPreeclampsiaen_US
dc.subjectWıpı-2 Expressionen_US
dc.titleWIPI-2 protein expression increases in the placentas of patients with preeclampsiaen_US
dc.titleWIPI-2 protein expression increases in the placentas of patients with preeclampsia
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu