EFFECTS OF ERYTHROPOIETIN ON THE SERUM AND LIVER TISSUE LEVELS OF COPPER AND ZINC IN RATS WITH OBSTRUCTIVE JAUNDICE

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dc.contributor.authorAliosmanoglu, Ibrahim
dc.contributor.authorKapan, Murat
dc.contributor.authorGul, Mesut
dc.contributor.authorArikanoglu, Zulfu
dc.contributor.authorOnder, Akin
dc.contributor.authorTaskesen, Fatih
dc.contributor.authorBasarili, Mustafa Kemal
dc.date.accessioned2024-04-24T17:20:20Z
dc.date.available2024-04-24T17:20:20Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Erythropoietin is an anti-apoptotic, anti-inflammatory, angiogenetic cytokine and has protective properties against oxidative stress. In this study we investigated the effects of erythropoietin on the levels (serum and liver tissue) of copper and zinc in cholestatic rats. Methods: Thirty-two Wistar albino rats used in the study were divided into four groups Group I: Sham; Group II: Erythropoietin; Group III: Obstructive Jaundice; Group IV: Obstructive Jaundice+Erythropoietin. After the first operation, rats were followed up for seven days and then operated for the second time. Rats were sacrificed by intracardiac blood taking, and the liver tissue samples were obtained immediately. Results: Erythropoietin reduces copper, and increases zinc levels in serum and liver tissues after obstructive jaundice (p<0.05). Furthermore, it has been shown that the levels of alanine aminotransferase, aspartate aminotransferase, gamma glutamyl transferase, alkaline phosphatase and total bilirubin/direct bilirubin were significantly lower in Obstructive Jaundice+ Erythropoietin group than Obstructive Jaundice group. Conclusions: Erythropoietin affects the changes in copper and zinc levels, thus decreasing the liver damage biochemically in rats with obstructive jaundice. However; further investigations are needed to discover how erythropoietin therapy might reduce target organ damage in cholestatic liver cases by affecting copper and zinc levels.en_US
dc.identifier.doi10.2478/v10011-012-0012-3
dc.identifier.endpage51en_US
dc.identifier.issn1452-8258
dc.identifier.issn1452-8266
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84875431058
dc.identifier.scopusqualityQ3
dc.identifier.startpage47en_US
dc.identifier.urihttps://doi.org/10.2478/v10011-012-0012-3
dc.identifier.urihttps://hdl.handle.net/11468/18958
dc.identifier.volume32en_US
dc.identifier.wosWOS:000312464800008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherSciendoen_US
dc.relation.ispartofJournal of Medical Biochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectObstructive Jaundiceen_US
dc.subjectErythropoietinen_US
dc.subjectLiver Damageen_US
dc.subjectCopperen_US
dc.subjectZincen_US
dc.titleEFFECTS OF ERYTHROPOIETIN ON THE SERUM AND LIVER TISSUE LEVELS OF COPPER AND ZINC IN RATS WITH OBSTRUCTIVE JAUNDICEen_US
dc.titleEFFECTS OF ERYTHROPOIETIN ON THE SERUM AND LIVER TISSUE LEVELS OF COPPER AND ZINC IN RATS WITH OBSTRUCTIVE JAUNDICE
dc.typeArticleen_US

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