Serum prolidase Activity in Ankylosing spondylitis and Rheumatoid Arthritis

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dc.contributor.authorUcar, Demet
dc.contributor.authorEm, Serda
dc.contributor.authorBozkurt, Mehtap
dc.contributor.authorOktayoglu, Pelin
dc.contributor.authorYuksel, Hatice Kurt
dc.contributor.authorCaglayan, Mehmet
dc.contributor.authorGezer, Orhan
dc.date.accessioned2024-04-24T17:24:17Z
dc.date.available2024-04-24T17:24:17Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of the present study was to emphasize the collagen turnover in 2 of the most common chronic inflammatory rheumatic diseases by evaluating serum prolidase activity (SPA) in ankylosing spondylitis (AS) and rheumatoid arthritis (RA). 30 patients who met the modified New York Criteria for the classification of AS, 29 patients who met the 2010 Rheumatoid Arthritis Classification Criteria for the classification of RA, and 31 healthy controls were enrolled in the study. Serum samples of the patients and the controls were collected and SPA was measured by a spectrophotometric method. The comparison of the SPA in these 3 groups was statistically examined. In both patient groups, the SPA was lower than in the control group. SPA in patients with AS was statistically significantly lower than in the control and RA groups (P, 0.001/P = 0.002). No statistically significant difference was found between the RA and the control groups (P = 0.891). In conclusion, lower SPA is presumably associated with decreased collagen turnover and fibrosis, leading to decreased physical functions in both chronic inflammatory musculoskeletal diseases.en_US
dc.identifier.doi10.4137/CMAMD.S12602
dc.identifier.endpage33en_US
dc.identifier.issn1179-5441
dc.identifier.pmid23966806
dc.identifier.startpage29en_US
dc.identifier.urihttps://doi.org/10.4137/CMAMD.S12602
dc.identifier.urihttps://hdl.handle.net/11468/19589
dc.identifier.volume6en_US
dc.identifier.wosWOS:000215651100004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofClinical Medicine Insights-Arthritis and Musculoskeletal Disorders
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnkylosing Spondylitisen_US
dc.subjectRheumatoid Arthritisen_US
dc.subjectSerum Prolidase Activityen_US
dc.titleSerum prolidase Activity in Ankylosing spondylitis and Rheumatoid Arthritisen_US
dc.titleSerum prolidase Activity in Ankylosing spondylitis and Rheumatoid Arthritis
dc.typeArticleen_US

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