Anticholinesterase and antioxidant activities of novel heterocyclic Schiff base derivatives containing an aryl sulfonate moiety

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dc.authorid0000-0003-4163-9962en_US
dc.contributor.authorKamalı, Ayfer
dc.contributor.authorÇakmak, Reşit
dc.contributor.authorBoğa, Mehmet
dc.date.accessioned2023-03-20T06:34:02Z
dc.date.available2023-03-20T06:34:02Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractIn this research, nine novel heterocyclic Schiff base derivatives (10-18) bearing an aryl sulfonate moiety were designed, synthesized for the first time, and characterized. Then, their inhibitory effects on acetyl- and butyrylcholinesterase (AChE and BChE) were investigated in vitro conditions. Moreover, their antioxidant activities were examined by DPPH and ABTS methods. The results indicated that some of the tested molecules had varying enzyme inhibition and antioxidant activities. We determined that compounds 8, 9, 14, 17, and 18 indicated inhibitory effects with IC50 values ranging from 89.30 to 111.28 mu M against BChE, respectively compared to standard compound galanthamine (IC50 = 125.88 mu M). On the other hand, of the molecules tested, only compound 5 (IC50 = 36.64 mu M) displayed inhibitory activity higher than galanthamine against AChE. In DPPH assay, compounds 15 (IC50 = 161.93 mu M), 16 (IC50 = 191.76 mu M) and 17 (IC50 = 107.55 mu M) showed higher antioxidant activity than BHT (IC50 = 203.50 mu M). On the other hand, it was determined in ABTS assay that Schiff bases 10-17 (except for compound 18) indicated higher antioxidant activity than BHT.en_US
dc.identifier.citationKamalı, A., Çakmak, R. ve Boğa, M. (2022). Anticholinesterase and antioxidant activities of novel heterocyclic Schiff base derivatives containing an aryl sulfonate moiety. Journal of the Chinese Chemical Society, 69(4), 731-743.en_US
dc.identifier.doi10.1002/jccs.202100511
dc.identifier.endpage743en_US
dc.identifier.issn0009-4536
dc.identifier.issn2192-6549
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85126212912
dc.identifier.scopusqualityQ2
dc.identifier.startpage731en_US
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1002/jccs.202100511
dc.identifier.urihttps://hdl.handle.net/11468/11446
dc.identifier.volume69en_US
dc.identifier.wosWOS:000768818100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorBoğa, Mehmet
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag GMBHen_US
dc.relation.ispartofJournal of the Chinese Chemical Society
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectAntioxidant activityen_US
dc.subjectAryl sulfonateen_US
dc.subjectCholinesterase inhibitorsen_US
dc.subjectHeterocyclic Schiff baseen_US
dc.titleAnticholinesterase and antioxidant activities of novel heterocyclic Schiff base derivatives containing an aryl sulfonate moietyen_US
dc.titleAnticholinesterase and antioxidant activities of novel heterocyclic Schiff base derivatives containing an aryl sulfonate moiety
dc.typeArticleen_US

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