Antioxidant, anticholinesterase activities and polyphenolic constituents of cones of algerian fir (Abies numidica) by LCESI- MS/MS with chemometric approach

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dc.contributor.authorDuru, Mehmet Emin
dc.contributor.authorErol, Ebru
dc.contributor.authorErtaş, Abdulselam
dc.contributor.authorKabouche, Zahia
dc.contributor.authorMostefa, Maya Belhadj
dc.contributor.authorMokaddem-Darouı, Habiba
dc.contributor.authorKabouche, Ahmed
dc.date.accessioned2024-04-24T19:13:10Z
dc.date.available2024-04-24T19:13:10Z
dc.date.issued2021
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe fractions (Fr.1-5) of the hydromethanolic extract of Abies numidica cones were studied for theirpolyphenol constituents, antioxidant, and anticholinesterase activities. The ?-carotene-linoleic acid, cupric reducingpower (CUPRAC), DPPH scavenging, and ABTS radical scavenging assays were used to determine antioxidant activity.Fr.3 exhibited the highest antioxidant activity in ABTS test (IC50: 1.29 ?g/mL), b-carotene-linoleic acid test (IC50: 18.6?g/mL) and CUPRAC (A0.5: 33.8 ?g/mL) assays. Three fractions (Fr.2-4) promising antioxidant activity were analyzedusing LC-MS/MS for their phenolic compositions. Taxifolin (155.9-2816.2 ?g analyte/g extract), hyperoside (353.0-2045.5 ?g/g), vanillin (1488.9-1529.9 ?g/g), tannic acid (1281.6-1416.8 ?g/g), rosmarinic acid (1063.1-1149.3 ?g/g),coumarin (683.0-772.6 ?g/g), quercetin (881.0 ?g/g), and catechin (277.7-400.2 ?g/g) were identified in the antioxidantfractions. Moreover, the anticholinesterase activity was also performed using the in vitro spectroscopic Ellman method.The antioxidant fractions exhibited moderate butyrylcholinesterase inhibitory activity. The multi-ware analysis wasperformed to understand the origin of bioactivities. According to principal component analysis, it is detected that thehyperoside, catechin, taxifolin, and tannic acid were responsible for the antioxidant activity. Therefore, the cones ofAbies numidica can be considered as potent antioxidant and anticholinesterase sources in food and pharmaceuticalindustries, commercially.en_US
dc.identifier.endpage237en_US
dc.identifier.issn2630-6344
dc.identifier.issue3en_US
dc.identifier.startpage230en_US
dc.identifier.trdizinid445717
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/445717
dc.identifier.urihttps://hdl.handle.net/11468/28423
dc.identifier.volume25en_US
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.relation.ispartofJournal of research in pharmacy (online)
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleAntioxidant, anticholinesterase activities and polyphenolic constituents of cones of algerian fir (Abies numidica) by LCESI- MS/MS with chemometric approachen_US
dc.titleAntioxidant, anticholinesterase activities and polyphenolic constituents of cones of algerian fir (Abies numidica) by LCESI- MS/MS with chemometric approach
dc.typeArticleen_US

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