Relation between pathogenesis of liver cirrhosis, hepatic encephalopathy and serum cytokine levels-what is the role of tumor necrosis factor-alpha?

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dc.contributor.authorGoral V.
dc.contributor.authorAtayan Y.
dc.contributor.authorKaplan A.
dc.date.accessioned2024-04-24T18:44:20Z
dc.date.available2024-04-24T18:44:20Z
dc.date.issued2010
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground and objective: Hepatic encephalopathy (HE) is a major complication characterized with neuropsychiatric symptoms that occurs as a consequence of acute or chronic liver disease. It's etiology and pathogenetical mechanisms are not clearly understood and probably it is multifactorial. There are some reported studies about the role of tumor necrosis factor-alpha (TNF-?) and other inflammatory cytokines on the pathogenesis of HE. In this study, we aimed to investigate the relation between pathogenesis of HE and TNF-?, IL-1?, IL-2R, IL-6, IL-8 and IL-10, relation between the severity of HE and the levels of these cytokines. Methods: Eighty patients with liver cirrhosis [50 patients with clinical findings of HE (group 1) and 30 without any symptoms of HE (group 2)] and 30 healthy controls (group 3) were included into the study. Serum TNF-?, IL-1 ?, IL-2R, IL-6, IL-8 and IL-l0 levels of patients and control subjects were studied with chemiluminescent method. Results: There were statistical difference between serum TNF-?, IL-1 ?, IL-2R, IL-6, IL-8 levels of patients with liver cirrhosis and healthy subjects (P < 0.05), and between patients with and without HE (P < 0.05). There was a correlation between the severity of liver cirrhosis according to Child-Pugh classification and cytokine levels. The severity of HE (grade 1-4) was closely related with cytokine levels, especially TNF-?. On the other hand, there was no relation between cytokine levels and the etiological factors. Conclusion: We found a positive correlation between serum inflammatory cytokine levels (TNF-?, IL-1?, IL-2R, IL-6, IL-8) and the severity of liver cirrhosis. In addition, our findings suggested that this relation is independent from etiological factors.en_US
dc.identifier.endpage18en_US
dc.identifier.issn1562-9023
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-77953463333
dc.identifier.scopusqualityN/A
dc.identifier.startpage12en_US
dc.identifier.urihttps://hdl.handle.net/11468/24658
dc.identifier.volume5en_US
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.relation.ispartofJournal of Chinese Clinical Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHepatic Encephalopathyen_US
dc.subjectLiver Cirrhosisen_US
dc.subjectTumor Necrosis Factor-?en_US
dc.titleRelation between pathogenesis of liver cirrhosis, hepatic encephalopathy and serum cytokine levels-what is the role of tumor necrosis factor-alpha?en_US
dc.titleRelation between pathogenesis of liver cirrhosis, hepatic encephalopathy and serum cytokine levels-what is the role of tumor necrosis factor-alpha?
dc.typeArticleen_US

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