Relation between pathogenesis of liver cirrhosis, hepatic encephalopathy and serum cytokine levels-what is the role of tumor necrosis factor-alpha?
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Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background and objective: Hepatic encephalopathy (HE) is a major complication characterized with neuropsychiatric symptoms that occurs as a consequence of acute or chronic liver disease. It's etiology and pathogenetical mechanisms are not clearly understood and probably it is multifactorial. There are some reported studies about the role of tumor necrosis factor-alpha (TNF-?) and other inflammatory cytokines on the pathogenesis of HE. In this study, we aimed to investigate the relation between pathogenesis of HE and TNF-?, IL-1?, IL-2R, IL-6, IL-8 and IL-10, relation between the severity of HE and the levels of these cytokines. Methods: Eighty patients with liver cirrhosis [50 patients with clinical findings of HE (group 1) and 30 without any symptoms of HE (group 2)] and 30 healthy controls (group 3) were included into the study. Serum TNF-?, IL-1 ?, IL-2R, IL-6, IL-8 and IL-l0 levels of patients and control subjects were studied with chemiluminescent method. Results: There were statistical difference between serum TNF-?, IL-1 ?, IL-2R, IL-6, IL-8 levels of patients with liver cirrhosis and healthy subjects (P < 0.05), and between patients with and without HE (P < 0.05). There was a correlation between the severity of liver cirrhosis according to Child-Pugh classification and cytokine levels. The severity of HE (grade 1-4) was closely related with cytokine levels, especially TNF-?. On the other hand, there was no relation between cytokine levels and the etiological factors. Conclusion: We found a positive correlation between serum inflammatory cytokine levels (TNF-?, IL-1?, IL-2R, IL-6, IL-8) and the severity of liver cirrhosis. In addition, our findings suggested that this relation is independent from etiological factors.
Açıklama
Anahtar Kelimeler
Hepatic Encephalopathy, Liver Cirrhosis, Tumor Necrosis Factor-?
Kaynak
Journal of Chinese Clinical Medicine
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
5
Sayı
1
