Effects of tamoxifen administration in rat vaginas: An ultrastructural and light microscopy study

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dc.contributor.authorKetani M.A.
dc.contributor.authorKetani Ş.
dc.contributor.authorKaloğlu C.
dc.contributor.authorGüney B.
dc.date.accessioned2024-04-24T18:43:55Z
dc.date.available2024-04-24T18:43:55Z
dc.date.issued2002
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Tamoxifen (TAM) inhibits the initiation of carcinogen induced rat mammary tumours and is administrered for extended periods after the initiation of carcinogenesis. It is also a widely used treatment for breast and gynaecological cancer. Objective: In this study, we aimed to investigate tamoxifen (TAM) administration on vagen development in rats. Material & Methods: Twenty sexually mature and pregnant Wistar albino rats were chosen as the animal model. They were divided into two groups. Group I: Control group, Group II: Tamoxifen applied (between gestational day 16 and 21 days); 100 ?g tamoxifen citrate (TAM) in 0.05 ml saline subcutaneously per day/animal. After birth, all female rats were sacrificed on the 60th day and were taken vaginal tissue. Transmission electron microscopy and light microscopy have been used to study changes to the vaginal epithelium. Results: A statistically significant reduction of birth body weight was noted in the experimental group of rats when compared to the control group (P<0.05). We saw increase in the thickness of the epithelium layer and irregularity and disappearance of microscopic papilla, cytoplasmic vacuolation in cells of the surface layer, thin and irregular basal membrane, lateral junction of cells were destroyed in the TAM treated groups. In conclusion, neonatal tamoxifen administration affects vagina epithelium and lead to decreasing birth body weight and vaginal adenosis.en_US
dc.identifier.endpage560en_US
dc.identifier.issn0392-2936
dc.identifier.issue6en_US
dc.identifier.pmid12556105
dc.identifier.scopus2-s2.0-0036940992
dc.identifier.scopusqualityN/A
dc.identifier.startpage557en_US
dc.identifier.urihttps://hdl.handle.net/11468/24460
dc.identifier.volume23en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.relation.ispartofEuropean Journal of Gynaecological Oncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdenosis-Like Lesionen_US
dc.subjectRaten_US
dc.subjectTamoxifenen_US
dc.subjectUltrastructural Changesen_US
dc.subjectVaginaen_US
dc.titleEffects of tamoxifen administration in rat vaginas: An ultrastructural and light microscopy studyen_US
dc.titleEffects of tamoxifen administration in rat vaginas: An ultrastructural and light microscopy study
dc.typeArticleen_US

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