THE ROLE OF ENDOTHELIAL NITRIC OXIDE SYNTHASE GENE POLYMORPHISM IN CLINICALLY CLASSIFIED PATIENTS WITH CORONARY ARTERY DISEASE

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dc.contributor.authorCakir, D. U.
dc.contributor.authorMete, N.
dc.date.accessioned2024-04-24T17:20:21Z
dc.date.available2024-04-24T17:20:21Z
dc.date.issued2010
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of the study was to investigate the relationship of eNOS (4 intron 27bp) polymorphism in clinically classified patients with coronary artery disease (CAD) in Turkish population PCR and restriction fragment length polymorphism analysis were used to detect the variant of the eNOS gene in 74 patients' with CAD and 20 healthy controls The CAD group was separated into 3 clinical groups depending on angiography criteria and clinical form designation 1st Group Myocardial infarction (MI) (n 20) 2nd Group Unstable Angina Pectoris (UAP) (n 18) 3rd Group Stable Angina Pectoris (SAP) (n 36) When a and b allele frequencies in the CAD and control groups we, e compared no statistically significant difference was found No significant difference was observed in the 4 intron 27 bp variants of the eNOS gene when CAD patients were compared without distinguishing them clinically from the control group When we assessed CAD patients classified according to their clinical form no significant difference was determined in allele frequencies and genotype distribution in the subgroups except for subgroup S4P When we compared SAP patients with the other subgroups and with the control group it was found that there was a significant increase in the ab genotype and the a allele frequency and a decrease in the bb genotype (p < 0 05) In conclusion CAD seemed to develop without any alterations in eNOS (4 intron 27bp) genotype frequency However the 27 bp repeat polymorphism of the eNOS gene in patients with SAP can be considered as SAP which may have a hereditary origin High eNOS gene polymorphism in patients with SAP can be related to the increased risk of possible coronary occurrence in future It was concluded that further studies of the relationship between eNOS gene polymorphism and CAD should take account of the clinical forms of CADen_US
dc.description.sponsorshipDicle Universityen_US
dc.description.sponsorshipThis study was supported by the Research Project Coordinators of Dicle Universityen_US
dc.identifier.doi10.2478/V10133-010-0083-6
dc.identifier.endpage2121en_US
dc.identifier.issn1310-2818
dc.identifier.issn1314-3530
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-78649779536
dc.identifier.scopusqualityQ3
dc.identifier.startpage2117en_US
dc.identifier.urihttps://doi.org/10.2478/V10133-010-0083-6
dc.identifier.urihttps://hdl.handle.net/11468/18969
dc.identifier.volume24en_US
dc.identifier.wosWOS:000284717900014
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnology & Biotechnological Equipment
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCoronary Artery Disease (Cad)en_US
dc.subjectMyocardial Infarction (Mi)en_US
dc.subjectUnstable Angina Pectoris (Uap)en_US
dc.subjectStable Angina Pectoris (Sap)en_US
dc.subjectAtherosclerosisen_US
dc.subjectNitric Oxide (No)en_US
dc.subjectEnos Gene Polymorphismen_US
dc.titleTHE ROLE OF ENDOTHELIAL NITRIC OXIDE SYNTHASE GENE POLYMORPHISM IN CLINICALLY CLASSIFIED PATIENTS WITH CORONARY ARTERY DISEASEen_US
dc.titleTHE ROLE OF ENDOTHELIAL NITRIC OXIDE SYNTHASE GENE POLYMORPHISM IN CLINICALLY CLASSIFIED PATIENTS WITH CORONARY ARTERY DISEASE
dc.typeArticleen_US

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