Gamma irradiation effects on diphenhydramine hydrochloride: an EPR study

Basit Öğe Kaydı
dc.authorid0000-0002-5791-1492en_US
dc.contributor.authorSütçü, Kerem
dc.contributor.authorAydın, Murat
dc.date.accessioned2024-11-08T06:49:58Z
dc.date.available2024-11-08T06:49:58Z
dc.date.issued2024en_US
dc.departmentDicle Üniversitesi, Ziya Gökalp Eğitim Fakültesi, Matematik ve Fen Bilimleri Eğitimi Bölümüen_US
dc.description.abstractThis study seeks to detect and characterize the free radicals generated in gamma-irradiated diphenhydramine hydrochloride (DP-HCl), a precursor for an antihistamine drug. The investigation aims to assess the radiation sensitivity of DP-HCl under varying microwave power, radiation doses, temperature conditions, and storage durations. After irradiation with 14 kGy, the observed radical associated with the –ĊHCH2N– fragment exhibited a singlet signal with a g-value of g = 2.0016 ± 0.0005. The signal intensities from experimental spectra within the 2–20 kGy dose range were found to exhibit the optimal fit with a polynomial function. Experimental spectra were recorded in the temperature range of 123–423 K to investigate whether distinct types of radicals were formed at low and high temperatures. Furthermore, the stability of the free radicals generated in the irradiated sample was assessed by determining the extinction curves of the signal intensities of the sample. The novelty of this study lies in examining the radiation sensitivity of the –ĊHCH2N– radical, demonstrating its remarkable stability across different temperatures and storage durations. This leads to the conclusion that radiation sterilization of the DP-HCl sample is not suitable.en_US
dc.description.sponsorshipFund of Dicle University (DUBAP) ZGEF.22.003en_US
dc.identifier.citationSütçü, K. ve Aydın, M. (2024). Gamma irradiation effects on diphenhydramine hydrochloride: an EPR study. Radiation Effects and Defects in Solids, 1-10.en_US
dc.identifier.endpage10en_US
dc.identifier.issn1042-0150
dc.identifier.scopus2-s2.0-85204552090
dc.identifier.scopusqualityQ3
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/10420150.2024.2405963
dc.identifier.urihttps://hdl.handle.net/11468/28933
dc.identifier.wosWOS:001316555200001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorSütçü, Kerem
dc.language.isoenen_US
dc.publisherTaylor and Francis Ltd.en_US
dc.relation.ispartofRadiation Effects and Defects in Solids
dc.relation.isversionof10.1080/10420150.2024.2405963en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiphenhydramine hydrochlorideen_US
dc.subjectElectron paramagnetic resonanceen_US
dc.subjectGamma irradiationen_US
dc.titleGamma irradiation effects on diphenhydramine hydrochloride: an EPR studyen_US
dc.titleGamma irradiation effects on diphenhydramine hydrochloride: an EPR study
dc.typeArticleen_US

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