The effectiveness of hemopoietic growth factors in sepsis

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dc.contributor.authorYilmaz G.
dc.contributor.authorAldemir M.
dc.contributor.authorYilmaz R.
dc.contributor.authorDiken H.
dc.contributor.authorBüyükbayram H.
dc.contributor.authorAkgün Y.
dc.date.accessioned2024-04-24T17:58:46Z
dc.date.available2024-04-24T17:58:46Z
dc.date.issued2001
dc.departmentDicle Üniversitesien_US
dc.description.abstractIn this experimental study, consist of 54 Sprague-Dawley rats, we tried to observe the effectiveness of haemopoietic growth factors such as G-CSF and GM-CSF in treatment of sepsis and see if they have any effects on phagocytic activity of macrophages when are administered after establishment of sepsis. In first phase of this study, twenty one rats were randomly divided into three groups of 7 animals each. Cecal ligation and perforation were carried out in each rat and sepsis made up. The Control group received 2 x 0.2 cc %5 dextrose injection subcutaneous (s.c.).. The G-CSF group received 2 x 1 g G-CSF with 0.2 cc %5 dextrose s.c. The GM-CSF received 1 x 2 g GM-CSF with 0.2 cc %5 dextrose s.c. Seventh day survival was considered as criterion in the three groups. In second phase of this study, thirty three rats were randomly divided into three groups of 11 animals each. The same procedures were carried out also in these groups. Leukocyte counts and peripheric spread were analyzed in postoperative 24th and 72th hours, alveolar and peritoneal macrophages were Investigated in postoperative 72nd hour. There was significantly neutrophilic leukocytosis in the G-CSF group according to the control group. Nevertheless, there was no change in the phagocytic activity of alveolar and peritoneal macrophages. GM-CSF brought about positive effect of phagocytic activity of macrophages without change of leucocyte count in the sepsis, but it caused neutrophilic, monocytosis and lymphocytopenia. The seventh day survival rates in control, G-CSF, GM-CSF groups were as; 42.8%, 71.4%, 28.5% respectively. As a result, we saw that G-CSF has no effect on the phagocytic activity of macrophages, while increases the survival by enhancing the count and probably the function of neutrophils. GM-CSF fails to increase survival while effects the phagocytic activities of macrophages positively and enhances the peripheral neutrophil and monosit counts without changing the total number of leukocytes.en_US
dc.identifier.endpage86en_US
dc.identifier.issn1300-6738
dc.identifier.issue2en_US
dc.identifier.pmid11705042en_US
dc.identifier.scopus2-s2.0-0035320352en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage82en_US
dc.identifier.urihttps://hdl.handle.net/11468/24091
dc.identifier.volume7en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isotren_US
dc.relation.ispartofUlusal travma dergisi = Turkish journal of trauma & emergency surgery : TJTESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleThe effectiveness of hemopoietic growth factors in sepsisen_US
dc.title.alternativeSepsiste hemopoetik büyüme faktörlerinin etkinligi.en_US
dc.typeArticleen_US

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