Evaluation of the medicinal potential of a traditionally important plant from Turkey: Cerinthe minor L.

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dc.authorid0000-0001-5784-7091en_US
dc.authorid0000-0003-4163-9962en_US
dc.contributor.authorErsoy, Ezgi
dc.contributor.authorKarahan, Selim
dc.contributor.authorBoğa, Mehmet
dc.contributor.authorÇınar, Ercan
dc.contributor.authorİzgi, Sevcan
dc.contributor.authorKara, Emel Mataracı
dc.date.accessioned2023-04-24T12:33:46Z
dc.date.available2023-04-24T12:33:46Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi Sağlık Bilimleri Uygulama ve Araştırma Merkezien_US
dc.description.abstractBackground and Aims: Cerinthe minor L. has been used for both culinary and medicinal purposes in Turkey. Since the plant has remained uninvestigated pharmacognostically, this study aims to provide data on the phytochemical profile and in vitro biological activities of the ethanol extract prepared from the aerial and root parts of Cerinthe minor L. Methods: The phytochemical profile of the extract was determined by LC-MS/MS. Total phenolic and total flavonoid contents of Cerinthe minor ethanol extract were determined as pyrocatechol, and quercetin equivalents, respectively. Antioxidant activity of the extract was investigated by DPPH, and ABTS cation radical scavenging activity, and CUPRAC activity assays. Enzyme inhibitory activity assays were used to investigate anticholinesterase, antityrosinase, and antiurease activities. Cytotoxic potential of the plant was clarified by using the XTT method, and antimicrobial activity of the extract was established by the microbroth dilution technique. Results: According to the LC-MS/MS results, 11 different constituents were present in the extract, and the major com-pounds were, malic acid (5392.18 +/- 60.93 mu g/g extract), fumaric acid (4730.99 +/- 58.66 mu g/g extract), and rosmarinic acid (2470.07 +/- 176.12 mu g/g extract). Total phenolic and flavonoid contents were found as 10.39 +/- 0.73 mu g PEs/mg extract, and 0.75 +/- 0.07 mu g QEs/mg extract, respectively. The extract demonstrated moderate antioxidant activity, whereas no enzyme inhibitory activity was exerted against the tested enzymes. No cytotoxic activity was observed on human renal (A498, UO-31) or human colon (COLO205, KM12) cancer cell lines. The extract was shown to possess low-moderate antimicrobial activity against C. tropicalis with a MIC value of 78.12 mu g/mL. Conclusion: Having several pharmacologically valuable compounds, and not causing any toxicity on studied cell lines, Cerin-the minor is a plant that requires attention with its medicinal potentialen_US
dc.description.sponsorshipDicle University-DUBAP: ECZACILIK.19.003en_US
dc.identifier.citationErsoy, E., Karahan, S., Boğa, M., Çınar, E., İzgi, S., Kara, E.M. ve diğerleri (2022). Evaluation of the medicinal potential of a traditionally important plant from Turkey: Cerinthe minor L. Istanbul Journal of Pharmacy, 52(1), 80-89.en_US
dc.identifier.doi10.26650/IstanbulJPharm.2022.1001685
dc.identifier.endpage89en_US
dc.identifier.issn2587-2087
dc.identifier.issue1en_US
dc.identifier.startpage80en_US
dc.identifier.trdizinid1127040
dc.identifier.urihttps://iupress.istanbul.edu.tr/en/journal/ijp/article/evaluation-of-the-medicinal-potential-of-a-traditionally-important-plant-from-turkey-cerinthe-minor-l
dc.identifier.urihttps://hdl.handle.net/11468/11736
dc.identifier.volume52en_US
dc.identifier.wosWOS:000793925000012
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorKarahan, Selim
dc.institutionauthorBoğa, Mehmet
dc.language.isoenen_US
dc.publisherIstanbul University Pressen_US
dc.relation.ispartofIstanbul Journal of Pharmacy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCerinthe minoren_US
dc.subjectLC-MSen_US
dc.subjectMSen_US
dc.subjectAntioxidanten_US
dc.subjectCytotoxicityen_US
dc.subjectMedicinal potentialen_US
dc.titleEvaluation of the medicinal potential of a traditionally important plant from Turkey: Cerinthe minor L.en_US
dc.titleEvaluation of the medicinal potential of a traditionally important plant from Turkey: Cerinthe minor L.
dc.typeArticleen_US

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