Nivolumab-Related Dry Mouth and Dry Eye: Cross-Sectional Study

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dc.contributor.authorYildirim, Ozgen Ahmet
dc.contributor.authorPoyraz, Kerem
dc.contributor.authorErdur, Erkan
dc.contributor.authorCan, Canan
dc.contributor.authorGundogan, Cihan
dc.contributor.authorGuzel, Yunus
dc.contributor.authorEtem, Hulya
dc.date.accessioned2024-04-24T16:24:36Z
dc.date.available2024-04-24T16:24:36Z
dc.date.issued2021
dc.departmentDicle Üniversitesien_US
dc.description.abstractTo evaluate ICIs related dry eye and dry mouth in nivolumab therapy, 24 patients receiving nivolumab (group 1), 30 patients in remission without treatment for 6 months (group 2), 30 healthy participants (group 3) were cross-sectionally examined. Schirmer's 1, 2, TSH blood tests, serological analysis, salivary flow scintigraphy and minor-salivary gland biopsy were performed. Schirmer's tests were performed with anesthetic (1) and without anesthetic (2). Schirmer's scores were lower in group 1 with more frequent reduced tear production (p < 0.001). TSH levels negatively correlated with Schirmer's scores. Functional insufficiency was detected by salivary flow scintigraphy in 7 out of 10 patients with Schirmer's test positivity. In Schirmer's positive patients, lymphocytic sialadenitis was confirmed in 4 patients (focus score > 1) and CD4 T lymphocyte precipitation was observed in 6 patients. Nivolumab therapy may be associated with ICIs related immune sicca.en_US
dc.identifier.doi10.1080/07357907.2021.1971241
dc.identifier.endpage807en_US
dc.identifier.issn0735-7907
dc.identifier.issn1532-4192
dc.identifier.issue10en_US
dc.identifier.pmid34415812en_US
dc.identifier.startpage797en_US
dc.identifier.urihttps://doi.org/10.1080/07357907.2021.1971241
dc.identifier.urihttps://hdl.handle.net/11468/16784
dc.identifier.volume39en_US
dc.identifier.wosWOS:000698272500001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofCancer Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectReduced Tear Productionen_US
dc.subjectNivolumaben_US
dc.subjectSchirmer'sen_US
dc.titleNivolumab-Related Dry Mouth and Dry Eye: Cross-Sectional Studyen_US
dc.typeArticleen_US

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