LC-MS /MS characterization and biological activities of Morina persica L. (Caprifoliaceae)

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dc.authorid0000-0002-0735-4229en_US
dc.authorid0000-0001-8451-3425en_US
dc.authorid0000-0002-9550-9111en_US
dc.authorid0000-0002-4090-7227en_US
dc.contributor.authorGözcü, Sefa
dc.contributor.authorAkşit, Zeynep
dc.contributor.authorŞimşek, Samed
dc.contributor.authorKandemir, Ali
dc.contributor.authorAydın, Ali
dc.contributor.authorYılmaz, Mustafa Abdullah
dc.contributor.authorAkşit, Hüseyin
dc.date.accessioned2024-11-06T06:05:02Z
dc.date.available2024-11-06T06:05:02Z
dc.date.issued2024en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractThe study aimed to comprehensively identify the phenolic fingerprint of Morina persica L. (Caprifoliaceae) and evaluate its various biological activities. LC-MS/MS analysis of 70% Morina persica methanol extract revealed the presence of 27 phytochemicals, with quinic acid, chlorogenic acid, and rutin being the major phenolics. The antioxidant, antibacterial, antiproliferative, and cytotoxic activities were evaluated for biological screening. The results showed that the methanolic extract of M. persica has a moderate DPPH radical scavenging and ferric-reducing capacity, indicating antioxidant activity. M. persica was observed to have a sufficient antiproliferative effect against cancer cells and low cytotoxicity against normal cells. Moreover, M. persica demonstrated good antibacterial activity against Clostridium perfringens, Enterococcus faecalis, and Escherichia coli. These data suggest that the methanolic extract of M. persica could be considered both an industrial source of quinic acid and a potential biologically active ingredient for developing drug formulations.en_US
dc.identifier.citationGözcü, S., Akşit, Z., Şimşek, S., Kandemir, A., Aydın, A., Yılmaz, M. A. ve diğerleri. (2024). LC-MS /MS characterization and biological activities of Morina persica L. (Caprifoliaceae). Journal of Research in Pharmacy, 28(4), 961-973.en_US
dc.identifier.endpage973en_US
dc.identifier.issn2630-6344
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85203502778
dc.identifier.scopusqualityQ3
dc.identifier.startpage961en_US
dc.identifier.urihttps://jrespharm.com/abstract.php?id=1655
dc.identifier.urihttps://hdl.handle.net/11468/28914
dc.identifier.volume28en_US
dc.identifier.wosWOS:001288934400006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorYılmaz, Mustafa Abdullah
dc.language.isoenen_US
dc.publisherMarmara Universityen_US
dc.relation.ispartofJournal of Research in Pharmacy
dc.relation.isversionof10.29228/jrp.779en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntibacterialen_US
dc.subjectAntioxidanten_US
dc.subjectAntiproliferativeen_US
dc.subjectLC-MS/MSen_US
dc.subjectMorina persica Len_US
dc.titleLC-MS /MS characterization and biological activities of Morina persica L. (Caprifoliaceae)en_US
dc.titleLC-MS /MS characterization and biological activities of Morina persica L. (Caprifoliaceae)
dc.typeArticleen_US

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