Is methotrexate an acceptable treatment in the management of idiopathic granulomatous mastitis?

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dc.contributor.authorAkbulut, Sami
dc.contributor.authorArikanoglu, Zulfu
dc.contributor.authorSenol, Ayhan
dc.contributor.authorSogutcu, Nilgun
dc.contributor.authorBasbug, Murat
dc.contributor.authorYeniaras, Erhan
dc.contributor.authorYagmur, Yusuf
dc.date.accessioned2024-04-24T16:00:18Z
dc.date.available2024-04-24T16:00:18Z
dc.date.issued2011
dc.departmentDicle Üniversitesien_US
dc.description.abstractPurpose The treatment of choice for idiopathic granulomatous mastitis (IGM) has not yet been established. There are limited data on the use of methotrexate (MTX) in the treatment of IGM. Herein, we investigated the role of MTX in the treatment of IGM patients. Methods We present four new cases of IGM treated with MTX and a review of the English language literature concerning the use of MTX in the treatment of IGM. Results We prospectively investigated the clinicopathological features of four female patients (aged 28-37 years) who were multiparous and had used oral contraceptives. The patients were administered 7.5-15 mg MTX over 2-6 months. No recurrence was detected during the follow-up period of 4-8 months. In five published studies on MTX use in IGM, data were available for 12 patients aged 21-40 years. In nine patients, treatment was changed to MTX because of a lack of response to steroids, recurrence or steroid-induced diabetes mellitus. Steroids were used in combination with MTX as an initial treatment choice in three patients. Satisfactory results were achieved in ten patients treated with MTX, and only two demonstrated recurrence despite the treatment and underwent mastectomy. Conclusion MTX in the present cases of IGM was effective, prevented complications and limited corticosteroid side effects.en_US
dc.identifier.doi10.1007/s00404-010-1825-2
dc.identifier.endpage1195en_US
dc.identifier.issn0932-0067
dc.identifier.issn1432-0711
dc.identifier.issue5en_US
dc.identifier.pmid21207047
dc.identifier.startpage1189en_US
dc.identifier.urihttps://doi.org/10.1007/s00404-010-1825-2
dc.identifier.urihttps://hdl.handle.net/11468/14432
dc.identifier.volume284en_US
dc.identifier.wosWOS:000295737300022
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofArchives of Gynecology and Obstetrics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMethotrexateen_US
dc.subjectIdiopathic Granulomatous Mastitisen_US
dc.subjectBreasten_US
dc.titleIs methotrexate an acceptable treatment in the management of idiopathic granulomatous mastitis?en_US
dc.titleIs methotrexate an acceptable treatment in the management of idiopathic granulomatous mastitis?
dc.typeArticleen_US

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