The protective effect of dexmedetomidine on bupivacaine-induced sciatic nerve inflammation is mediated by mast cells

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dc.contributor.authorTufek, Adnan
dc.contributor.authorKaya, Savas
dc.contributor.authorTokgoz, Orhan
dc.contributor.authorFirat, Ugur
dc.contributor.authorEvliyaoglu, Osman
dc.contributor.authorCelik, Feyzi
dc.contributor.authorKaraman, Haktan
dc.date.accessioned2024-04-24T17:44:25Z
dc.date.available2024-04-24T17:44:25Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractPurpose: This study was designed to assess the correlation between the neuroprotective effect of dexmedetomidine and oxidative stress, neural inflammation and mast cell stability in rats with bupivacaine-induced sciatic nerve toxicity. Methods: Forty adult Wistar Albino rats, eight rats per group, were used. Saline (0.3 ml of 0.9%), dexmedetomidine (20 mu g/kg), 0.5% bupivacaine or 0.5% bupivacaine+dexmedetomidine (20 mu g/kg) was injected into the sciatic nerve. A control group of rats received no injection. Fourteen days after injection, the sciatic nerves were harvested and total oxidant status, total anti-oxidant status, paraoxonase-1, galectin-3 and matrix metalloproteinase 2 and 9 levels were measured in the sciatic nerves. In addition, the presence and status of inflammation, edema, and mast cells were evaluated histopathologically. Results: The combination of dexmedetomidine and bupivacaine alleviated oxidative stress. In addition, it decreased matrix metalloproteinase 9 and galectin-3 levels and increased matrix metalloproteinase 2 levels. Moreover, it stabilized recruited mast cells at the injury site; however, it did not significantly decrease inflammation or edema. Conclusion: Dexmedetomidine may ameliorate bupivacaine-induced neurotoxicity by modulating mast cell degranulation. The neuroprotective effect of dexmedetomidine may make it a suitable adjuvant agent to local anesthetics in peripheral nerve blocks.en_US
dc.description.sponsorshipDicle University Scientific Research Project Coordination Unit (DUBAP), Diyarbakir, Turkey [10-TF-152]en_US
dc.description.sponsorshipThis work was supported by Dicle University Scientific Research Project Coordination Unit (DUBAP), Diyarbakir, Turkey (Grant No 10-TF-152).en_US
dc.identifier.endpageE102en_US
dc.identifier.issn0147-958X
dc.identifier.issue2en_US
dc.identifier.pmid23544611
dc.identifier.startpageE95en_US
dc.identifier.urihttps://hdl.handle.net/11468/22043
dc.identifier.volume36en_US
dc.identifier.wosWOS:000318765200006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherCanadian Soc Clinical Investigationen_US
dc.relation.ispartofClinical and Investigative Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleThe protective effect of dexmedetomidine on bupivacaine-induced sciatic nerve inflammation is mediated by mast cellsen_US
dc.titleThe protective effect of dexmedetomidine on bupivacaine-induced sciatic nerve inflammation is mediated by mast cells
dc.typeArticleen_US

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