Effects of Tarantula cubensis alcoholic extract and Nerium oleander distillate on experimentally induced colon cancer

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dc.contributor.authorEr, A.
dc.contributor.authorOzdemir, O.
dc.contributor.authorCoskun, D.
dc.contributor.authorDik, B.
dc.contributor.authorBahcivan, E.
dc.contributor.authorFaki, H. Eser
dc.contributor.authorYazar, E.
dc.date.accessioned2024-04-24T17:33:45Z
dc.date.available2024-04-24T17:33:45Z
dc.date.issued2019
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of this research was to determine the effects of Tarantula cubensis alcoholic extract (TCAE) and Nerium oleander distillation (NOD) on the colon aberrant cryptal foci (ACF) score, serum cytokines [Tumour necrosis factor (TNF)-alpha, interleukin (IL)-2, IL-6, IL-10], prostaglandin E2, and oxidative status parameters (malondialdehyde, superoxide dismutase, catalase, glutathione peroxidase) in an experimentally induced colon cancer model in rats. Male rats (38 in total) were divided into 4 groups: Control group (n = 8), Colon Cancer group (CC, n = 10), CC+TCAE group (n = 10), and CC i NOD group (n = 10). Except for the Control group, the rest of rats received azoxymethane (15 mg/kg, SC) once a week for two weeks to induce colon cancer. TCAE was administered once a week at 0.2 mL/kg (SC) and NOD was administered in water to CC+TCAE and CC+NOD groups for 18 weeks. After blood samples were collected, the rats were euthanized, colons were removed, washed with saline, then fixed with 10% formaldehyde, and stained with 0.2% methylene blue. ACFs were scored by light microscopy. Serum levels of cytokines, prostaglandin E2, and oxidative status parameters were determined with ELISA. ACF score of the CC group was higher than CC+TCAE and CC+NOD groups. The prostaglandin E2 level of the Control group was lower than the CC i TCAE group, while IL-2 and IL-10 levels of the Control group were lower than all other groups. In conclusion, it can be stated that TCAE and NOD applications may be beneficial in the treatment of colon cancer.en_US
dc.description.sponsorshipSUBAPK [17401073]en_US
dc.description.sponsorshipThis study was financed by SUBAPK (17401073). Study abstract was present as oral presentation in the International Conference on Veterinary, Agriculture and Life Sciences (ICVALS), October 26-29, 2018, Antalya, Turkeyen_US
dc.identifier.endpage21en_US
dc.identifier.issn0035-1555
dc.identifier.issn2258-0646
dc.identifier.issue1-3en_US
dc.identifier.scopus2-s2.0-85061377099
dc.identifier.scopusqualityQ3
dc.identifier.startpage15en_US
dc.identifier.urihttps://hdl.handle.net/11468/20827
dc.identifier.volume170en_US
dc.identifier.wosWOS:000458184200003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherEcole Nationale Veterinaire Toulouseen_US
dc.relation.ispartofRevue De Medecine Veterinaire
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTarantula Cubensis Alcoholic Extracten_US
dc.subjectNerium Oleander Distillateen_US
dc.subjectColon Canceren_US
dc.titleEffects of Tarantula cubensis alcoholic extract and Nerium oleander distillate on experimentally induced colon canceren_US
dc.titleEffects of Tarantula cubensis alcoholic extract and Nerium oleander distillate on experimentally induced colon cancer
dc.typeArticleen_US

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